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Stand: 20.12.01 17:53

 Live Update

Auf dieser Seite finden Sie die Links auf alle aktuelle Berichte (Poster, Vorträge, Interviews) direkt aus Chicago. Die Liste wird ständig ergänzt mit neuen Berichten, wobei die aktuellsten Beiträge immer oben hinzugefügt werden.. Zum Anschauen der Beiträge klicken Sie auf das Video- bzw. Poster-Symbol in der letzten Spalte.

Zeitpunkt

Session

Titel / Beschreibung

Autoren / Interviewdetails

 

Mittwoch, 19.12.01

 

Was gab es neues auf der ICAAC und Bill Craigs neueste PK/PD - Daten.

Prof. Dr. William Craig, Madison, WI, USA

poster 

Mittwoch, 19.12.01

 

Was gab es neues auf der ICAAC.

Prof. Dr. George Drusano, Albany, NY

poster 

Mittwoch, 19.12.01,
10:00 Uhr

 

MRSA - die Situation in den USA und PK/PD von Piperacillin / Tazobactam.

Dr. David Nicolau, Hartford, CT, USA

video 

Mittwoch, 19.12.01,
09:30 Uhr

 

MHK - Bestimmung und Optimierung der Therapie nach PK/PD - Prinzipien.

Dr. Johan Mouton, Nijmegen, Holland

video 

Mittwoch, 19.12.01,
10:00 - 11:30 Uhr

230. In Vitro Susceptibility: Miscellaneous

2264. Surveillance of Susceptibility Patterns in 1297 European and US Anaerobic and Micro-Aerophilic Isolates to Amoxicillin/Clavulanic Acid (A/C) and 5 Other Agents

L. M. KOETH1, M. R. BISCOTTI1, P. C. APPELBAUM2, L. J. DUBREUIL3, E. J. C. GOLDSTEIN4, A. C. RODLOFF5;
1Laboratory Specialists Inc, Cleveland, OH, 2Hershey Medical Center, Hershey, PA, 3University of Lille, Lille, France, 4RM Alden Research Foundation, Los Angeles, CA, 5University of Leipzig, Leipzig, Germany.

poster
P.1

poster
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Mittwoch, 19.12.01,
10:00 - 11:30 Uhr

230. In Vitro Susceptibility: Miscellaneous

2264. Surveillance of Susceptibility Patterns in 1297 European and US Anaerobic and Micro-Aerophilic Isolates to Amoxicillin/Clavulanic Acid (A/C) and 5 Other Agents

L. M. KOETH1, M. R. BISCOTTI1, P. C. APPELBAUM2, L. J. DUBREUIL3, E. J. C. GOLDSTEIN4, A. C. RODLOFF5;
1Laboratory Specialists Inc, Cleveland, OH, 2Hershey Medical Center, Hershey, PA, 3University of Lille, Lille, France, 4RM Alden Research Foundation, Los Angeles, CA, 5University of Leipzig, Leipzig, Germany.

poster 

Mittwoch, 19.12.01,
10:00 - 11:30 Uhr

224. Antimicrobial Pharmaco

2197. Influence of Linezolid (L), Penicillin (P), and Clindamycin (C), Alone and in Combination, on Streptococcal Pyrogenic Exotoxin A (SPE A) Release

E.A. COYLE1, R. CHA2, M.J. RYBAK2,3;
1The Univ. of Houston Coll. of Pharmacy, Houston, TX, 2The Anti-Infective Res. Lab., Coll. Of Pharmacy and Allied Health Professions, Wayne State Univ., Detroit, MI, 3Sch. of Med., Detroit, MI.

poster
P.1

poster
P.2

Mittwoch, 19.12.01,
10:00 - 11:30 Uhr

224. Antimicrobial Pharmaco

2190. Pharmacodynamic (PD) Evaluation of Extending the Infusion Time of Piperacillin/tazobactam (P/T) Doses Using Monte Carlo Analysis (MC)

B. M. LOMAESTRO1, K. A. RODVOLD2, L. H. DANZIGER2, G. L. DRUSANO3;
1Albany Medical Center Hospital, Albany, NY, 2University of Illinois College of Pharmacy, Chicago, IL, 3Albany Medical College, Albany, NY.

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P.5

Mittwoch, 19.12.01,
8:30 - 10:00 Uhr

217. Pharmacodynamics of Antimicrobials II: In Vivo Models

2096. Pharmacodynamic (PD) Parameters of Linezolid Associated with Efficacy vs. Streptococcus pneumoniae-Induced Acute Otitis Media (AOM) in Gerbils

W. HUMPHREY, M. SHATTUCK, K. KOLBASA, R. ZIELINSKI, M. KUO, R. SCHAADT, G. ZURENKO, I. RICHARDS;
Pharmacia Corp., Kalamazoo, MI.

poster
P.1

poster
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Mittwoch, 19.12.01,
8:30 - 10:00 Uhr

217. Pharmacodynamics of Antimicrobials II: In Vivo Models

2089. In Vivo Pharmacodynamic Activity of Ceftriaxone against Viridans Streptococci: Implications for Susceptibility Breakpoints

W. A. CRAIG, D. ANDES;
Univ. of Wisconsin and VA Hosp., Madison, WI.

poster 

Mittwoch, 19.12.01,
8:30 - 10:00 Uhr

216. Pharmacodynamics of Antimicrobials I: In Vitro Models

2088. Pharmacodynamic Studies of Different Dosage Regimens of Amoxicillin/ Clavulanic Acid Including a New Slow-Release Formulation against in an In Vitro Kinetic Model

INGA ODENHOLT1, E. LÖWDIN2, O. CARS3;
1Dep. of Infectious Diseases, University Hospital, Malmö, Sweden, 2University Hospital, Uppsala, Sweden, 3University hospital, Uppsala, Sweden.

poster 

Mittwoch, 19.12.01,
8:30 - 10:00 Uhr

216. Pharmacodynamics of Antimicrobials I: In Vitro Models

2077. Pharmacodynamics of Penicillin in Combination Therapy Using Penicillinase in an In Vitro Kinetic Model

ELISABETH M. LÖWDIN, I. ODENHOLT, S. BENGTSSON, O. CARS;
University Hospital, Uppsala, Sweden.

poster
P.1

poster
P.2

Mittwoch, 19.12.01,
8:30 - 10:00 Uhr

216. Pharmacodynamics of Antimicrobials I: In Vitro Models

2076. Pharmacodynamics of Moxifloxacin vs Eythromycin against Intracellular in an In Vitro Kinetic Model

E. TANO, E. LÖWDIN, O. CARS;
University Hospital, Uppsala, Sweden.

poster 

Dienstag 18.12.01,
13:00 Uhr

 

ICAAC 2001 Highlights: Surveillance - Studien und "Cycling" von Antibiotika.

Interview mit Prof. Rodloff, Leipzig

video 

Dienstag, 18.12.01,
3:00 - 4:30 Uhr

189. Meningitis

1860. Evaluation of Ertapenem (ETP) against Penicillin-Sensitive and -Resistant Pneumococci in the Experimental Meningitis Model

PH. COTTAGNOUD1, F. ACOSTA2, M. COTTAGNOUD2, M. G. TÄUBER3;
1Dept. Internal Medicine, Inselspital, Bern, Switzerland, 2Dept. Internal Medicine, Zieglerspital, Bern, Switzerland, 3Inst. for Infectious Diseases, University of Bern, Bern, Switzerland.

poster 

Dienstag 18.12.01, 2:00 - 4:30 Uhr

185. Pediatric Infectious Diseases

1826. Short Course Antibiotic Therapy of Streptococcal Pharyngitis: Comparison of Clarithromycin with Amoxicillin/Clavulanate and Cefuroxime Axetil

D. ADAM1, H. SCHOLZ2, H. HAVERKAMP3, M. HELMERKING3;
1Dept. of Antimicrobial Therapy, Dr. v. Haunersches Children's Hosp., Univ. of Munich, Munich, Germany, 2Inst. for Infectiology, Microbiol. and Hygienics, Municipal Hosp. Buch, Berlin, Germany, 3Algora Clin. Res. Organization, Munich, Germany.

presentation 

Dienstag, 18.12.01,
13:30 - 15:00 Uhr

171. Animal Models

1660. Efficacy of Gatifloxacin and Moxifloxacin Compared to Ciprofloxacin against Experimental Yersinia pestis Infection in Balb/c Mice

J. A. STEWARD, P. R. RUSSELL, T. J. G. BROOKS;
DERA, Salisbury, United Kingdom.

poster 

Dienstag, 18.12.01

 

Klinische Überlegenheit von Linezolid gegenüber Glykopeptiden? Siehe auch Beitrag 1481.

Interview mit M. Wilcox, Universitätsklinik Leeds, UK

video 

Dienstag, 18.12.01, 11:00 - 12:30 Uhr

164. Clinical Candidiasis and Aspergillosis

1624. A Double-Blind Study of Fluconazole Oral Suspension vs.Capsules in the Treatment of Oropharyngeal Candidiasis in HIV-Patients

M. EICHEL1, C. SCHNEIDER2, G. JUST-NUEBLING2;
1University Hospital, Frankfurt/Main, Germany, 2university hospital, Frankfurt/Main, Germany.

poster 

Dienstag, 18.12.01, 11:00 - 12:30 Uhr

163. Animal Models of Mycoses

1604. Evaluation of Voriconazole Efficacy in the Treatment of Murine Fusariosis

G. H. REYES1, L. LONG2, M. HOSSAIN2, M. A. GHANNOUM1;
1Case Western Res. U./University Hosp., Cleveland, OH, 2Case Western Reserve University, Cleveland, OH.

poster
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poster
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poster
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Dienstag, 18.12.01, 11:00 - 12:30 Uhr

163. Animal Models of Mycoses

1603. Development of a Quantitative PCR Assay to Measure Aspergillus fumigatus Burden in a Murine Model of Disseminated Aspergillosis: Demonstration of the Efficacy of Caspofungin

J. C. BOWMAN, G. K. ABRUZZO, J. W. ANDERSON, A. M. FLATTERY, C. J. GILL, V. B. PIKOUNIS, D. M. SCHMATZ, P. A. LIBERATOR, C. M. DOUGLAS;
Merck and Co., Inc., Rahway, NJ.

poster 

Dienstag, 18.12.01, 9:30 - 11:00 Uhr

156. Staphylococcal and Streptococcal Infections

1481. Linezolid versus Teicoplanin for the Treatment of Hospitalized Patients with Gram-Positive Infections

M. WILCOX1, T. TANG2, B. HAFKIN2;
1Leeds General Infirmary, Univ of Leeds, Leeds, United Kingdom, 2Pharmacia Corp, Peapack, NJ.

poster 

Dienstag, 18.12.01, 9:30 - 11:00 Uhr

155. Ventilator-Associated Pneumonia

1469. Linezolid Efficacy in the Treatment of Ventilator-Associated Nosocomial Pneumonia

S. K. CAMMARATA, T. H. OLIPHANT, K. A. HEMPSALL;
Pharmacia, Kalamazoo, MI.

poster 

Dienstag, 18.12.01, 9:30 - 11:00 Uhr

151. Nosocomial Infections IV: Legionella and Other Outbreaks

1444. Nosocomial Sepsis Caused by Pandoraea pnomenusa Highly Resistant to Meropenem but Sensitive to Imipenem in Two Oncology Patients

JAN P. ARENDS, LIEKE V.M. MÖLLER, RIENK Y.J. TAMMINGA;
Academic Hospital Goningen, Groningen, Netherlands.

poster 

Dienstag, 18.12.01, 9:30 - 11:00 Uhr

149. Linezolid In Vitro

1421. Uptake and Intracellular Activity of Linezolid in Human Phagocytic and Tissue Cultured Epithelial Cells

A. PASCUAL, S. BALLESTA, I. GARCÍA, E. J. PEREA;
University of Seville, Seville, Spain.

poster 

Dienstag, 18.12.01, 9:30 - 11:00 Uhr

149. Linezolid In Vitro

1414. Evaluation of Linezolid Potency on Gram-Positive Cocci in an Austrian Multi-Center Study

H. MITTERMAYER, C. JEBELEAN, ON BEHALF OF THE ALPS GROUP;
Elisabethinen Hospital, Linz, Austria.

poster 

Montag 17.12.01,
3:00 - 4:30 Uhr

125. Nosocomial Infections in Immunosuppressed Hosts

1251. Oral Flora and Mucositis Grade During Myeloablative Chemotherapy

H. LOEVENICH1, C. KEULERTZ1, H. SCHUETT-GEROWITT2, U. BETHE1, D. SOEHNGEN1, D. WALDSCHMIDT1, O. A. CORNELY1;
1University of Cologne, Dept. of Internal Med., Cologne, Germany, 2University of Cologne, Inst. of Microbiol., Cologne, Germany.

poster 

Montag 17.12.01,
15:00 - 16:30 Uhr

122. Nosocomial Infections I: Staphylococcus aureus

1227. Use of Mupirocin to Prevent Methicillin Resistant Staphylococcus aureus (MRSA) Orthopedic Surgical Site Infections (SSIs)

J. HALL, M. H. WILCOX, H. PIKE, P. TEMPLETON, W. N. FAWLEY, P. PARNELL, P. VERITY;
Dept of Microbiology & Infection Control, The General Infirmary & University of Leeds, Leeds, United Kingdom.

poster 

Montag 17.12.01,
15:00 - 16:30 Uhr

122. Nosocomial Infections I: Staphylococcus aureus

1224. Risk Factors Associated with Methicillin-Resistant Staphylococcus aureus (MRSA)

R. A. VENEZIA, E. M. GRAFFUNDER, A. M. EVANS;
Albany Medical Center, Albany, NY.

poster 

Montag 17.12.01,
15:00 - 16:30 Uhr

119. Antibiotic Resistance in Healthcare Settings

1194. Risk Factors Associated with the Development of Enterococcal Resistance to Linezolid

M. P. PAI, R. D. GONZALES, J. M. PETROLATI, M. B. GRAHAM, P. C. SCHRECKENBERGER, K. A. RODVOLD, J. P. QUINN;
University of Illinois at Chicago, Chicago, IL.

poster 

Montag 17.12.01,
3:00 - 4:30 Uhr

119. Antibiotic Resistance in Healthcare Settings

1193. Emergence of Linezolid-Resistant Enterococcus faecium in the Gastrointestinal (GI) Tract during Treatment of Vancomycin-Resistant Enterococcal (VRE) Infections

M. BASSETTI, D.A.CALLAN, L.M. DEMBRY, P.A. FARREL, J.E.TOPAL;
Yale Univ. School of Med. and Yale New Haven Hosp., New Haven, CT.

poster 

Montag 17.12.01,
3:00 - 4:30 Uhr

119. Antibiotic Resistance in Healthcare Settings

1186. Risk Factors for Piperacillin-Tazobactam-Resistant Pseudomonas aeruginosa among Hospitalized Patients

ANTHONY D. HARRIS1, E. P. PERENCEVICH1, M. C. ROGHMANN1, J. G. MORRIS1, K. S. KAYE2, J. A. JOHNSON1;
1Univ. of Maryland, Baltimore, MD, 2Duke Univ., Durham, NC.

poster
P.1

poster
P.2

poster
P.3

Montag 17.12.01,
15:00 Uhr

100. Ketolide Susceptibility Studies

Mikrobiologie von ABT-773. Siehe auch Beitrag 1001.

Interview mit PD Dr. von Eiff, Münster

video 

Montag 17.12.01,
14:30 Uhr

 

Clinical Pharmacy in the US
Research Studies presented at ICAAC 2001

Interview mit Dr. D. Nicolau, Hartford, CT, USA

video 

Montag 17.12.01,
14:00 Uhr

 

"The higher the better" - PK/PD Views of an expert.

Interview mit Prof. Dr. C. Nightingale, Hartford, CT, USA

video 

Montag 17.12.01,
13:30 Uhr

 

Pneumokokken-Impfstoffe in der Pädiatrie

Interview mit Prof. Dr. Dr. Dr. h.c. mult. Dieter Adam, München

video 

Montag 17.12.01,
13:00 Uhr

185. Pediatric Infectious Diseases

Pharyngitis-Studie; Diskussion der Ergebnisse. Siehe auch Beitrag 1826.

Interview mit Prof. Dr. Dr. Dr. h.c. mult. Dieter Adam, München

video 

Montag 17.12.01, 13:30 - 15.00 Uhr

103. Urinary Tract Infections

1053. A Large Multicenter, Double-Blind Study of Ertapenem (ETP) vs. Ceftriaxone (CTX) in Complicated Urinary Tract Infections (CUTI)

K. TOMERA1, E. BURDMANN2, O. PAMO3, R. GESSER4, Q. JIANG4, W. WIMMER4, THE PROTOCOL 014 STUDY GROUP;
1Alaska Clin. Res. Center, Anchorage, AK, 2Sao Jose do Rio Preto Med. School, Sao Paulo, Brazil, 3Peruvian Univ. Cayetano Heredia of Lima, Lima, Peru, 4Merck Res. Labs., West Point, PA.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

102. Novel Oxazolidinones II

1048. Synthesis and Antibacterial Activity of Pyrrolopyridine-Substituted Oxazolidinones

J. HILLIARD, R. GOLDSCHMIDT, J. FERNANDEZ, J. MELTON, S. PAGET, M. WEIDNER-WELLS, M. MACIELAG, K. BUSH;
The R.W. Johnson Pharmaceutical Res. Inst., Raritan, NJ.

poster
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poster
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poster
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Montag 17.12.01, 13:30 - 15.00 Uhr

101. Novel Oxazolidinones I: AZD-2563

1026. In Vitro Activity of a Novel Oxazolidinone, AZD2563, against Gram-Positive Cocci, Including Diverse Multi-Resistant Isolates

A. P. JOHNSON, M. WARNER, T. PARSONS, D. M. LIVERMORE;
Central Publ. Health Lab., Colindale, London, United Kingdom.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

101. Novel Oxazolidinones I: AZD-2563

1025. The New Oxazolidinone, AZD2563: the Effect of pH, Inoculum, Serum and Media Type on Antibacterial Activity

P. J. TURNER, A. WOOKEY, J. M. GREENHALGH, M. EASTWOOD, J. CLARKE, J. CLARKE;
AstraZeneca, Macclesfield, Cheshire, United Kingdom.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

101. Novel Oxazolidinones I: AZD-2563

1024. Investigations into the Antibacterial Spectrum of the New Oxazolidinone, AZD2563, against Recent Clinical Isolates from North America and Europe

P. J. TURNER, A. WOOKEY, J. M. GREENHALGH, M. EASTWOOD, J. CLARKE;
AstraZeneca, Macclesfield, Cheshire, United Kingdom.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

101. Novel Oxazolidinones I: AZD-2563

1023. In Vivo Studies of Novel Oxazolidinones with O- and N-linked C-5 Heterocyclic Side-Chains, Including AZD2563

M. B. GRAVESTOCK, M. J. BETTS, E. CHAWNER, L. DAWSON, A. MCGREGOR, S. D. MILLS, R. G. WILSON, L. WOODS, A. WOOKEY;
AstraZeneca, Macclesfield, Cheshire, United Kingdom.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1018. In Vitro Activity of Telithromycin against Clinical Isolates of Streptococcus pneumoniae Collected from 214 Medical Centers across the United States during the Winter of 2000/2001

C. W. STRATTON1, A. BARRY2, Y. C. YEE3;
1Vanderbilt Univ., Nashville, TN, 2CMI, Wilsonville, OR, 3Aventis Pharma, Bridgewater, NJ.

poster
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Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1008. In Vitro Activity of ABT-773 vs. Macrolide-Susceptible and -Resistant S. pneumoniae, H. influenzae and M. catarrhalis: Results of a 2 Year (1999/2000 and 2000/2001) Canadian Respiratory Organism Surveillance Study (CROSS)

G. G. ZHANEL1, A. WIERZBOWSKI1, A. NOREDDIN1, K. NICHOL2, D. J. HOBAN2;
1University of Manitoba, Winnipeg, MB, Canada, 2Health Sciences Centre, Winnipeg, MB, Canada.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1007. In Vitro Activity of ABT-773 and Six Other Antibacterial Agents against Recent Community-Acquired Respiratory Tract Isolates: a German Multicenter Study

S. BAGEL, J. BRAUERS, M. KRESKEN;
Antiinfectives Intelligence, Bonn, Germany.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1006. Susceptibility of Respiratory Pathogens in Great Britain to ABT-773, a New Ketolide Antibiotic

THOMAS B. LYTLE, NICHOLAS G. WARWICK, STEVE J. COLES;
Abbott Laboratories, Maidenhead, United Kingdom.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1005. A Multi-Center Study Comparing the Activity of a Novel Ketolide ABT-773 with Beta-Lactams, Macrolides and Fluoroquinolones against Respiratory Tract Pathogens isolated in 2000-2001 in the the Province of Quebec, Canada

K. WEISS1, C. RESTIERI1, H. GUAY1, P. DOLCE2, L. A. GALARNEAU3, P. HARVEY3, JF PARADIS2, H. SENAY2, AND THE GRAM NETWORK2, D. E. LOW4, C. LAFERRIERE2, I. LECORRE2;
1Hopital Maisonneuve-Rosemont, Montreal, Canada, 2GRAM, Montreal, Canada, 3The Gram Network, Montreal, PQ, Canada, 4Mount Sinai Hospital, Toronto, Canada.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1004. In Vitro Activity of ABT-773, a Novel Ketolide, against Clinical Isolates of Gram-Positive and Gram-Negative Cocci

M. INOUE, Y. SATO, R. OYAUCHI, R. OKAMOTO;
Kitasato Univ., Kanagawa, Japan.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1003. Mutation Prevention Concentration (MPC) of ABT-773 (ABT) versus Four Other Agents against Streptococcus pneumoniae (SP) and Haemophilus influenzae (HF)

M. M. NEUHAUSER1, J. L. PRAUSE2, S. L. PENDLAND2;
1University of Houston, Houston, TX, 2University of Illinois at Chicago, Chicago, IL.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1002. Activity of a New Ketolide ABT-773 In Vitro against S. pneumoniae Non-Susceptible to Penicillin or Macrolides

EDWARD O. MASON1, L. B. LAMBERTH2, S. L. KAPLAN1, U.S. MULTICENTER PNEUMOCOCCAL SURVEILLANCE GROUP;
1Baylor College of Medicine, Houston, TX, 2Texas Children's Hospital, Houston, TX.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

100. Ketolide Susceptibility Studies

1001. Comparative In Vitro Activity of ABT-773 and Two Macrolides against Staphylococci

C. VON EIFF, G. PETERS;
Inst. of Med. Microbiol., Univ. of Münster, Hosp. and Clin., Münster, Germany.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

995. Efficacy of Linezolid in MRSA and Vancomycin-Insensitive Staphylococcus aureus (VISA) Hematogenous Pulmonary Infection Model

K. YANAGIHARA, Y. KANEKO, M. KUROKI, Y. MIYAZAKI, Y. HIRAKATA, K. TOMONO, T. TASHIRO, S. KOHNO;
Nagasaki University, Nagasaki, Japan.

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Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

994. Gatifloxacin: Efficacy in the Chinchilla Model of Streptococcus pneumoniae Acute Otitis Media

JD SWARTS1,2, J. BATTI1,2, J. BANKS1, J. SEROKY1;
1Children's Hospital of Pittsburgh, Pittsburgh, PA, 2Univ. Pittsburgh Sch. Med., Pittsburgh, PA.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

993. The In Vivo Activities of ABT-773 in Mouse Models of Respiratory Tract Infection Due to Streptococcus pneumoniae and Haemophilus influenzae

T. FUJIKAWA, S. MIYAZAKI, Y. ISHII, N. FURUYA, A. OHNO, T. MATSUMOTO, K. TATEDA, K. YAMAGUCHI;
Toho University School of Medicine, Tokyo, Japan.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

992. ABT-773 Demonstrates Bactericidal Effects against Susceptible and Resistant Streptococcus pneumoniae and Haemophilus influenzae in Rat Pulmonary Infection

M. MITTEN, J. MEULBROEK, A. TOVCIMAK, G. WILKERSON, J. STAVROPOULOS, N. RAMER, A. NILIUS, Z. MA AND R. FLAMM;
Abbott Laboratories, Abbott Park, IL.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

990. Effect of Serum Protein Binding on the Outcome of Therapy with Gemifloxacin

V. BERRY, R. STRAUB, G. WOODNUTT;
GlaxoSmithKline, Collegeville, PA.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

988. Efficacy of a Pharmacokinetically Enhanced Formulation of Amoxicillin/Clavulanate against Experimental Respiratory Tract Infection (RTI) in Rats Caused by Streptococcus pneumoniae (Sp)

V. BERRY, C. SINGLEY, J. SATTERFIELD, G. WOODNUTT;
GlaxoSmithKline, Collegeville, PA.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

099. Respiratory Infections

986. Effectiveness of ABT-773 in an Experimental Model of Multidrug-Resistant (MDR) Streptococcus pneumoniae (Sp) Bacteremic

I. C. MICHELOW, R. D. HARDY, K. OLSEN, J. IGLEHART, B. B. ROGERS, H. JAFRI, G. H. MCCRACKEN, O. RAMILO;
Univ. of TX Southwestern Med. Ctr., Dallas, TX.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

097. Human Pharmacokinetics of Antimicrobials

952. Clinical Safety of Pharmacokinetically Enhanced Amoxicillin/Clavulanate Compared with Currently Approved Formulations of Amoxicillin/Clavulanate

M-P RICHARD1, B. WYNNE2;
1GlaxoSmithKline, Harlow, United Kingdom, 2GlaxoSmithKline, Collegeville, PA.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

097. Human Pharmacokinetics of Antimicrobials

946. Tissue Penetration of Cefditoren (CEE) into Bronchial Mucosa (BM) and Epithelial Lining Fluid (ELF) in Patients Undergoing Fiberoptic Bronchoscopy

M. KINZIG-SCHIPPERS1, M. HINDER2, K. GÖHLER2, U. LOOS3, F. VOGEL4, F. SORGEL1;
1IBMP, Nürnberg, Germany, 2Grünenthal GmbH, Aachen, Germany, 3Knappschaft Hosp., Recklinghausen, Germany, 4Hosp. Internal Medicine, Hofheim a. T., Germany.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

097. Human Pharmacokinetics of Antimicrobials

942. Human Disposition and Metabolism of Orally Administered [14C]ABT773

Z. GUAN, S. FUKUMOTO, L. FAN, J. UCHIC, S. RAJA, K. MARSH, S. ROBERTS, M. EMERY;
Abbott Laboratories, Abbott Park, IL.

poster 

Montag 17.12.01, 13:30 - 15.00 Uhr

097. Human Pharmacokinetics of Antimicrobials

941. ABT-773 Has No Clinically-Important Effect on the Pharmacokinetics and Safety of Theophylline

LINDA E. GUSTAVSON, X. YE, J. BEASON, T. CHIRA, M. EWEN, M. PARIS, L. WILLIAMS;
Abbott Labs, Abbott Park, IL.

poster 

Montag 17.12.01, 11:00 - 12:30 Uhr

087. Sexually Transmitted Diseases

888. Results of a Phase III Randomized, Double-Blind Study of Ertapenem (ETP) vs Piperacillin/Tazobactam (P/T) for Acute Pelvic Infection (Inf) in Women

S. ROY1, I. HIGAREDA2, E. ANGEL-MULLER3, M. ISMAIL4, B. DEYI5, C. HAGUE5, H. TEPPLER5, PROTOCOL 023 STUDY GROUP;
1Keck Sch. of Med.@USC, Los Angeles, CA, 2Nuevo Hos. Civil, Guadalajara, Mexico, 3Univ. Nacional de Col., Bogota, Colombia, 4Univ. of Chicago, Chicago, IL, 5Merck Res. Labs., West Point, PA.

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Montag 17.12.01, 11:00 - 12:30 Uhr

085. Community-Acquired Pneumonia

870. Full Course Oral Levofloxacin vs. Intravenous (Ceftriaxone±Clarithromycin)-to-Oral Sequential Antibiotic Therapy for Patients Hospitalized with Community-Acquired Pneumonia (CAP)

V. A. ERARD, P.-Y. BOCHUD, A. COMETTA, J. BILLE, O. LAMY AND T.CALANDRA;
CHUV, Lausanne, Switzerland.

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Montag 17.12.01, 11:00 - 12:30 Uhr

085. Community-Acquired Pneumonia

855. A Double-Blind, Multicenter, Randomized, Phase III Study of Ertapenem (ETP) vs. Ceftriaxone (CTX) for Treatment of Serious Community-Acquired Pneumonia (CAP)

N. VETTER1, E. CAMBRONERO-HERNANDEZ2, J. ROHLF3, S. SIMON4, A. SINGER5, R. ISAACS5, T. OLIVERIA5, THE PROTOCOL 020 STUDY GROUP;
1Pulmonary Ctr. of the City of Vienna, Vienna, Austria, 2Hosp. Cristiano Jerusalem, San Jose, Costa Rica, 3St. Francis Med. Ctr., Trenton, NJ, 4Southeast Res. Associates, Austell, GA, 5Merck Res. Labs., West Point, PA.

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Montag 17.12.01, 11:00 - 12:30 Uhr

082. Azole Antifungals In Vitro

816. Novel Effect of Voriconazole on Conidiation and Pigmentation of Aspergillus Species

N. L. VARANASI, I. BASKARAN, G. J. ALANGADEN, P. H. CHANDRASEKAR, E. K. MANAVATHU;
Wayne State University, Detroit, MI.

poster 

Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

807. In Vitro Activities of MK-0826 and Parenteral ß-Lactam Antimicrobials against Clinical Isolates of ESBL-Producing Klebsiella pneumoniae and in an Isogenic Host

K. M. OLSEN, J.C. MCNABB, P.D. FEY, M.E. RUPP;
University of Nebraska Medical Center, Omaha, NE.

poster 

Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

806. Ertapenem (ETP), a New Antimicrobial: Comparative In Vitro Activity against Clinically Significant Anaerobes

K. E. ALDRIDGE, D. ASHCRAFT;
Louisiana State University Health Sciences Center, New Orleans, LA.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

805. Pseudomonas aeruginosa Resistance to Imipenem (IMI), Ertapenem (ETP) and Other Antibiotics: Results of a Multicenter ICU Study

I. R. FRIEDLAND, S. HARM, L. STINSON, D. GALLAGHER;
Merck & Co, West Point, PA.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

804. Comparative Activity of MK-0826 (Ertapenem) against Canadian Respiratory Isolates of Streptococcus pneumoniae (SPN) and Haemophilus influenzae (HI)

D. J. HOBAN1, L. PALATNICK1, B. WESHNOWESKI1, K. NICHOL1, G. G. ZHANEL2;
1Health Sciences Centre, Winnipeg, MB, Canada, 2University of Manitoba, Winnipeg, MB, Canada.

poster 

Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

803. Comparative In Vitro Activity of Ertapenem against Respiratory Tract Bacterial Pathogens

PATRICIA SCOTT HICKS, L. CHERRY, K. DORSO, L. GERCKENS, L. LYNCH, M. ROSENBACH, P. SINCLAIR, D. SUBER, B. A. PELAK, M. R. MOTYL;
Merck and Co., Inc, Rahway, NJ.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

796. Susceptibility to Faropenem among Recent U.S. Isolates of S. pneumoniae, H. influenzae, and M. catarrhalis

D. F. SAHM1, D. C. DRAGHI1, I. A. CRITCHLEY1, K. MURFITT1, M. E. JONES2, C. THORNSBERRY1, J. A. KARLOWSKY1;
1Focus Technologies/MRL, Herndon, VA, 2Focus Technologies/MRL, Hilversum, Netherlands.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

795. In Vitro Activity of Faropenem (FAR) against Genetically Characterized Isolates of Moraxella catarrhalis and Streptococcus pneumoniae

F. J. SCHMITZ1, M. BOOS1, S. MAYER1, J. VERHOEF2, D. MILATOVIC2, A. C. FLUIT2;
1Univ. Hosp. Dusseldorf, Dusseldorf, Germany, 2Univ. Hosp Utrecht, Utrecht, Netherlands Antilles.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

794. Bactericidal Activity of Faropenem (FAR) vs. Other Oral Antibiotics against Recent Respiratory Tract Isolates

I. MORRISSEY, D. BESTE, M. ROBBINS;
GR Micro Ltd, London, United Kingdom.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

793. In Vitro Activity of Faropenem against Pediatric Isolates

D. ADAM;
Klinikum Innenstadt der LMU, Munich, Germany.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

792. In Vitro Activity of Faropenem (FAR) against Gram-Positive and Gram-Negative Bacteria

D. MILATOVIC, A. C. FLUIT, J. VERHOEF;
Eijkman-Winkler Institute, University Utrecht, Utrecht, Netherlands Antilles.

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Montag 17.12.01, 11:00 - 12:30 Uhr

081. Carbapenems In Vitro

791. Faropenem: Activity against ESBL, AmpC, and Other ß-Lactamase-Producing  Enterobacteriaceae

J. A. BLACK1, E. SMITH MOLAND1, T. J. LOCKHART2, P. D. LISTER2, K. S. THOMSON1;
1Dept. Med. Microbiol. & Immunol., Creighton Univ. Sch. of Med., Omaha, NE, 2Dept. Med. Microbiol. & Immunol., Creighton Univ. Sch. of Med., omaha, NE.

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Montag 17.12.01, 09:30 - 11:00 Uhr

079. Infections in Neutropenic Patients

776. Piperacillin/Tazobactam (PTZ) Use in Febrile Neutropenic Patients (FNP): a Meta-Analysis

V. ZAROTSKY, G. S. JARESKO, P. D. HOLTOM;
University of Southern California Schools of Pharmacy and Medicine, Los Angeles, CA.

poster 

Montag 17.12.01, 09:30 - 11:00 Uhr

079. Infections in Neutropenic Patients

774. An EORTC-IATG Double-Blind Trial of Vancomycin (Van) versus Placebo (Pla) for Persistent Fever in Neutropenic Cancer Patients (NCP) given Piperacillin/tazobactam (PT) Monotherapy

A. COMETTA, W. V. KERN, R. DEBOCK, M. PAESMANS, M. VANDENBERGH, F. CROKAERT, D. ENGELHARD, O. MARCHETTI, H. AKAN, H. BASSARIS, V. KORTEN, C. VISCOLI, M. P. GLAUSER, FOR THE INTERNATIONAL ANTIMICROBIAL THERAPY GROUPOF THE EORTC;
CHUV, Lausanne, Switzerland.

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Montag 17.12.01, 09:30 - 11:00 Uhr

079. Infections in Neutropenic Patients

771. Cefepime Plus Amikacin versus Piperacillin-Tazobactam Plus Amikacin in the Treatment of Patients with Fever and Granulocytopenia

L. GOMEZ, C. ESTRADA, I. GOMEZ, M. MARQUEZ, D. DALMAU, C. ESTANY, J. M. MARTI, J. GARAU;
Hospital Mutua Terrassa, Barcelona, Spain.

poster 

Montag 17.12.01, 09:30 - 11:00 Uhr

078. Gastrointestinal Infections

763. Piperacillin/Tazobactam (PTZ) Use in the Treatment of Intra-Abdominal Infections (IAI): a Meta-Analysis

V. ZAROTSKY, G. S. JARESKO, P. D. HOLTOM;
University of Southern California Schools of Pharmacy and Medicine, Los Angeles, CA.

poster 

Montag 17.12.01, 09:30 - 11:00 Uhr

076. BMS-284756 and Other Fluoroquinolones In Vitro

735. Activity of Gemifloxacin, Ciprofloxacin and Levofloxacin against 8579 Respiratory Isolates Collected Worldwide in 2000

L. M. KOETH1, M. R. JACOBS2, D. FELMINGHAM3, J. A. POUPARD4, L. A. MILLER4, K. SAUNDERS4;
1Laboratory Specialists Inc, Westlake, OH, 2CWRU, Cleveland, OH, 3GR Micro Ltd, London, United Kingdom, 4GlaxoSmithKline, Collegeville, PA.

poster 

Montag 17.12.01, 09:30 - 11:00 Uhr

076. BMS-284756 and Other Fluoroquinolones In Vitro

726. Effect of Gemifloxacin on Viability of Chlamydia pneumoniae (Cpn) in a Continuous Infection Model In Vitro

A. KUTLIN, P. M. ROBLIN, M. R. HAMMERSCHLAG;
SUNY Downstate Medical Center, Brooklyn, NY.

poster 

Montag 17.12.01, 09:30 - 11:00 Uhr

075. Pneumococci, Fluoroquinolones and Resistance

708. Quinolone-Resistant Pneumococci from Croatia

GLENN A. PANKUCH1, K. NAGAI1, B. BOZDOGAN1, A. TAMBIC2, S. SCHOENWALD2, T. TAMBIC3, S. KALENIC4, S. PLESKO5, N. KUCISEC6, Z. KOTARSKI7, M. PAL8, P. APPELBAUM1;
1Hershey Medical Center, Hershey, PA, 2Univ Hospital of Infectious Diseases, Zagreb, Croatia, 3Croatian Acad Med Sci and Clin Hospital, Zagreb, Croatia, 4Rebro, Zagreb, Croatia, 5Univ Hospital of infectious Diseases, Zagreb, Croatia, 6Sveti Duh Hospital, Zagreb, Croatia, 7Univ Hospital Lung Diseases, Zagreb, Croatia, 8Public Health Lab, Cakovec, Croatia.

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Montag 17.12.01, 09:30 - 11:00 Uhr

075. Pneumococci, Fluoroquinolones and Resistance

705. Activities of Respiratory Fluoroquinolones against Penicillin-Resistant S. pneumoniae Isolated in Six European Countries in 2000-01

M. E. JONES1, J. A. KARLOWSKY2, I. A. CRITCHLEY2, K. MURFITT2, R. S. BLOSSER2, C. THORNSBERRY2, D. F. SAHM2;
1Focus Technologies/MRL, Hilversum, Netherlands, 2Focus Technologies/MRL, Herndon, VA

poster
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Montag 17.12.01, 09:30 - 11:00 Uhr

075. Pneumococci, Fluoroquinolones and Resistance

702. Prevalence of Single Mutations in Topoisomerase IV and DNA Gyrase among US Levofloxacin Susceptible Clinical Isolates of Streptococcus pneumoniae

T. DAVIES1, S. PFLEGER1, A. EVANGELISTA1, K. BUSH2, D. SAHM3, R. GOLDSCHMIDT2;
1Ortho-McNeil Pharmaceutical, Raritan, NJ, 2The R. W. Johnson Pharmaceutical Res. Inst., Raritan, NJ, 3Focus Technologies, Herndon, VA.

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Sonntag 16.12.01, 15:00 - 16:30 Uhr

049. GAR-936 Susceptibility Studies

525. Comparison of the In Vitro Activity of GAR-936 with Tetracycline, Minocycline, and Doxycycline in Isolates of Nontuberculous Mycobacteria

R. J. WALLACE JR, B. A. BROWN-ELLIOTT, C. J. CRIST, R. J. WALLACE;
The University of Texas Health Center, Tyler, TX.

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Sonntag 16.12.01, 15:00 - 16:30 Uhr

049. GAR-936 Susceptibility Studies

521. In Vitro Activity of GAR-936 against Gram-Positive and Gram-Negative Bacteria

DANA MILATOVIC, A. C. FLUIT, J. VERHOEF;
Eijkman Winkler Institute, Utrecht, Netherlands.

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Sonntag 16.12.01, 14:00 - 16:30 Uhr

042. Emergence and Prevention of Quinolone Resistance

441. The Magnitude of the Pharmacodynamic Parameters which Predict Fluoroquinolone Antibacterial Effect (ABE) and Emergence of Resistance (EoR) Are Not Uniform for All Species

A. P. MACGOWAN, K. E. BOWKER;
BCARE, Bristol, United Kingdom.

poster 

Sonntag 16.12.01, 14:00 - 16:30 Uhr

042. Emergence and Prevention of Quinolone Resistance

440. The Pharmacodynamics of Emergence of Resistance (EoR) to Moxifloxacin in S. pneumoniae (Sp) and P. aeruginosa (Pa) Explored in an In Vitro Model of Infection

A. P. MACGOWAN, K. E. BOWKER;
BCARE, Bristol, United Kingdom.

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Sonntag 16.12.01, 14:00 - 16:30 Uhr

042. Emergence and Prevention of Quinolone Resistance

438. Comparative Activity of Mutant Prevention Concentration (MPC)-Derived Dosages of Moxifloxacin (MXF) and Levofloxacin (LEV) against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model (IVPM)

G. P. ALLEN1, M. J. RYBAK1,2;

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Sonntag 16.12.01, 11:00 - 12:30 Uhr

013. Quinolone Resistance

148. Mutation Rates of Acinetobacter baumannii against Gemifloxacin, Moxifloxacin and Ciprofloxacin

P. G. HIGGINS1, K. COLEMAN2, S. G. B. AMYES1;
1University of Edinburgh, Edinburgh, United Kingdom, 2GlaxoSmithKline, Collegeville, PA.

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Sonntag 16.12.01, 11:00 - 12:30 Uhr

013. Quinolone Resistance

142. Mechanisms of Resistance to Gemifloxacin in Comparison to Ciprofloxacin in Staphylococcus aureus

D. INCE, L. C. SILVER, D. C. HOOPER;
Massachusetts General Hospital, Boston, MA.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

007. Surveillance of Antimicrobial Resistance

79. Nationwide Survey of Pathogen Frequency and Antimicrobial Susceptibility Patterns from Community Hospitals throughout the United States

K. W. GAREY1, M. MANDURU2, V. GUPTA2, L. H. DANZIGER1;
1University of Illinois at Chicago, Chicago, IL, 2Owen Healthcare, Inc, Chicago, IL.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

007. Surveillance of Antimicrobial Resistance

65. Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program, USA: Trends in Resistance (R), Molecular Epidemiology and Antimicrobial Usage

MICHAEL A. PFALLER1, R. N. JONES2, MYSTIC PARTICIPANTS GROUP2;
1University of Iowa College of Medicine, Iowa City, IA, 2The JONES Group/JMI Laboratories, North Liberty, IA.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

006. Resistance in Bacteria of Gastrointestinal Origin

64. Trends in Antimicrobial Resistance of the Bacteroides fragilis Group over an 11-Year Period (1989-2000)

C. BETRIU1, M. GOMEZ2, I. RODRIGUEZ-AVIAL2, B. A. SANCHEZ2, J. J. PICAZO2;
1Hospital Clinico San Carlos, Madrid, Spain, 2HOSPITAL CLINICO SAN CARLOS, MADRID, Spain.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

006. Resistance in Bacteria of Gastrointestinal Origin

62. Antibiotic Resistance among 547 Anaerobes from Chicago Area Medical Centers

DAVID W. HECHT, J. R. OSMOLSKI;
Loyola University Medical Center, Maywood, IL.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

005. Pharmacokinetics of Quinolones in Children and Adults

49. Pharmacodynamic Activity of Gatifloxacin on Streptococcus pneumoniae and Staphylococcus aureus in Skin Blister Fluid

A. TRAMPUZ, U. FLUCKIGER, G. LAIFER, W. ZIMMERLI;
University Hospitals, Basel, Switzerland.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

005. Pharmacokinetics of Quinolones in Children and Adults

48. Possible Role of Drug Photodegradation in Fluoroquinolone (FQ)-Induced Phototoxicity in Mice

E. WAKABAYASHI, Y. KITAMURA, Y. KUNINISHI, C. KOBAYASHI, N. ISHIKAWA, Y. MASUMOTO, H. KUSAJIMA;
Res. Ctr., Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.

 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

005. Pharmacokinetics of Quinolones in Children and Adults

42. Single-Dose Pharmacokinetics and Tolerability of Intravenous Levofloxacin in Pediatric Patients

S. CHIEN1, R. ABELS1, J. BLUMER2, A. CHOW1, H. GOLDSTEIN1, G. KEARNS3, S. MALDONADO4, G. NOEL1, T. WELLS5, S. SPIELBERG4;
1The R.W.Johnson Pharmaceutical Research Institute, Raritan, NJ, 2Rainbow Babies and Children's Hospital PPRU, Cleveland, OH, 3Children’s Mercy Hospital PPRU, Kansas City, MO, 4Janssen Research Foundation, Titusville, NJ, 5Arkansas Children's Hospital PPRU, Little Rock, AR.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

005. Pharmacokinetics of Quinolones in Children and Adults

39. Single Dose Safety and Pharmacokinetics (PK) of Intravenous (IV) Gatifloxacin in Pediatric Patients

M. AVILA-AGUERO1, J. BLUMER2, J. BRADLEY3, X. SAEX-LLORENS4, M. O'RYAN5, D. GRASELA6, F. LACRETA6, M. SWINGLE6, G. MCCRACKEN7, H. JAFRI7;
1Hosp. Nacional de Ninos, San Jose, Costa Rica, 2Case Western Reserve PPRU, Cleveland, OH, 3UC San Diego Children's Hosp. PPRU, San Diego, CA, 4Hosp. del Nino, Ciudad de Panama, Panama, 5Univ. de Chile, Santiago, Chile, 6Bristol-Myers Squibb, Princeton, NJ, 7UT Southwestern Med. Ctr., Dallas, TX.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

005. Pharmacokinetics of Quinolones in Children and Adults

38. Population Pharmacokinetic Analysis of Gatifloxacin in Pediatric Patients

C. RUBINO1, B. CIRINCIONE1, R. PENDLETON1, D. GRASELA2;
1Cognigen Corp., Buffalo, NY, 2Bristol-Myers Squibb, Princeton, NJ.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

005. Pharmacokinetics of Quinolones in Children and Adults

37. Gatifloxacin in Children with Recurrent Otitis Media (ROM): Application of Real-Time Data Assembly (RTDA) and Sparse PK Sampling in Clinical Development

D. GRASELA1, C. RUBINO2, F. LACRETA1, A. ARGUEDAS3, L. SHER4, E. LOPEZ5, X. SAEZ-LORENZ6, M. SWINGLE1, B. CIRINCIONE2, M. SOKOLOWSKI2, P. PIERCE1;
1Bristol-Myers Squibb, Princeton, NJ, 2Cognigen Corp., Buffalo, NY, 3Inst. Costarricense de Investigaciones Clin., San Jose, Costa Rica, 4Peninsula Res. Inst., Rolling Hills Est., CA, 5Hosp. de Ninos "Ricardo Gutierrez", Buenos Aires, Argentina, 6Hosp. del Nino, Ciudad de Panama, Panama.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals

31. Fluconazole in Anuric Patients Undergoing Continuous-Veno-Venous-Hemodialysis (CVVHD): Pharmacokinetics and Dosage Simulation

S. C. MUELLER1, J. MAJCHER-PESZYNSKA1, R. G. MUNDKOWSKI1, H. HICKSTEIN2, B. DREWELOW1;
1Clinical Pharmacology, University of Rostock, Rostock, Germany, 2Nephrology, University of Rostock, Rostock, Germany.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals

22. Potentiation of Voriconazole (VCZ) Ocular Penetration by Topical Latanoprost (LT) Co-Administration

W. E. SPONSEL1, V. BERNALL1, G. PARIS2, Y. TRIGO1, M. PENA1, R. GLICKMAN1, J. R. GRAYBILL1;
1The Univ. of TX Health Sci. Ctr. at San Antonio, San Antonio, TX, 2The Univ. of Tx Health Sci. Ctr. at San Antonio, San Antonio, TX.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals

21. Voriconazole Inhibition of Tacrolimus Metabolism after Liver Transplantation and in Human Liver Microsomes

N. SINGH, S. ZHANG, T. GAYOWSKI, R. VENKATARAMANAN;
Univ. of Pitts., Pittsburgh, PA.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals

17. Pharmacokinetics of Intravenous Voriconazole in Children after Single and Multiple Dose Administration

T. J. WALSH1, A. ARGUEDAS2, T. DRISCOLL2, P. ADAMSON2, M. KARLSSON2, N. WOOD3, P. MILLIGAN4, I. LUTSAR4;
1Voriconazole Pediatric Study Group, Bethesda, MD, 2Voriconazole Pediatric Study Group, BETHESDA, MD, 3Pfizer Global Research and Development, Sandwich, Kent, United Kingdom, 4Pfizer Global Research and Development, SANDWICH, Kent, United Kingdom.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals

16. Multiple-Dose Pharmacokinetics of Voriconazole in Chronic Hepatic Impairment

K. K. C. TAN1, N. WOOD2, A. WEIL3;
1Pfizer Global Research and Development, Sandwich, Kent, United Kingdom, 2Pfizer Global Research and Development, SANDWICH, Kent, United Kingdom, 3APEX Research, Munich, Germany.

poster 

Sonntag 16.12.01, 9:30 - 11:00 Uhr

004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals

14. Effect of Hepatic Insufficiency on the Pharmacokinetics of Caspofungin

J. STONE1, S. HOLLAND1, S. LI1, P. WICKERSHAM1, P. DEUTSCH1, G. WINCHELL1, M. HESNEY1, S. BI1, M. FRIEL1, G. MISTRY1, S. DILZER2, K. LASSETER2;
1Merck Research Laboratories, West Point, PA, 2Clinical Pharmacology Associates, Miami, FL.

poster 

Samstag 15.12.01, 17.15 Uhr

Vorsymposium

PROTEKT – Beschreibung eines neuen Surveillance Programmes.  www.protekt.org.
Symposiumsunterlagen

Interview von Dr. Harding, UK
mit Prof. Grünberg, UK

video 

Samstag, 15.12.01, 16.15 Uhr

Vorsymposium

Interview von Frau OÄ Dr. Grabein und Herrn OA Dr. Bodmann über die Behandlung der nosokomialen Pneumonie

Interview von Dr. med. B. Grabein mit Dr. med. K.-F. Bodmann

video