|
|
Zeit |
Session |
Beitrag |
Autoren |
Institution |
Die
Präsentation |
Sunday, 9:30 a.m. - 11:30 a.m. |
002. New Antimicrobial Agents |
12. BAY 41-4109 : a Novel Anti-HBV Agent |
ARNOLD PAESSENS1, ERWIN GRAEF1, KARL DERES1, ULRICH NIEWOEHNER1, JUERGEN STOLTEFUSS1, FRANK KROETLINGER1, BERND HERBOLD1, RAINER JAEGER1, ARMIN KERN1, BERND BECKERMANN1, DIETER HAEBICH1, HELGA RUEBSAMEN-WAIGMANN1, RALF N. A. MASANTSCHEK1, DIANA KOLETZKI1, WILLIAM S. MASON2, CLAUS H. SCHROEDER3, KARL-HEINZ SCHLEMMER1, ELKE HARTMANN1, OLAF WEBER1, SIEGFRIED GOLDMANN1, STEFAN WOHLFEIL1; |
1Bayer AG, Wuppertal, Germany, 2Fox Chase Cancer
Center, Philadelphia, PA, 3German Cancer Research Center, Heidelberg, Germany. |
|
Sunday, 9:30 a.m. - 11:00 a.m. |
004. Human Pharmacokinetics and Drug-Drug Interactions of Antifungals |
31. Fluconazole in Anuric Patients Undergoing
Continuous-Veno-Venous-Hemodialysis (CVVHD): Pharmacokinetics and Dosage
Simulation |
S. C. MUELLER1, J. MAJCHER-PESZYNSKA1, R. G. MUNDKOWSKI1, H. HICKSTEIN2, B. DREWELOW1; |
1Clinical Pharmacology,
University of Rostock, Rostock, Germany, 2Nephrology, University of Rostock, Rostock, Germany. |
|
Sunday, 9:30 a.m. - 11:00 a.m. |
005. Pharmacokinetics of Quinolones in Children and Adults |
40. Influence of Charcoal on the Gastro-Intestinal Circulation of
Moxifloxacin (MFX) in Healthy Male Volunteers |
HEINO H. STASS1, D. KUBITZA2, J.-G. MOELLER2; |
1Pharma Research Center, Bayer
AG, Wuppertal, Germany, 2Pharma research center, Bayer AG, Wuppertal, Germany. |
|
Sunday, 9:30 a.m. - 11:00 a.m. |
007. Surveillance of Antimicrobial Resistance |
71. Longitudinal Change of Antibiotic Susceptibility of Pseudomonas
aeruginosa in Cystic Fibrosis |
B. PRZYKLENK1, A. BAUERNFEIND2; |
1University Children's
Hospital, München, Germany, 2MICOER-Institute, München, Germany. |
|
Sunday, 9:30 a.m. - 11:00 a.m. |
008. Pneumococcal Vaccines |
85. Immunogenicity, Reactogenicity and Safety of a 7-Valent Pneumococcal
Conjugate Vaccine (7VPnC) Given Concomitantly with a 5-Component DTaP-IPV-Hib
Vaccine |
H. SCHMITT1, J. FABER1, I. BARTELS2, B. SCHMOELE-THOMA3, N. AHLERS3; |
1Univ.-Children's Hosp., Mainz,
Germany, 2Univ.-Children's Hosp., Erlangen, Germany, 3Wyeth Pharma GmbH,
Muenster, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
013. Quinolone Resistance |
146. Selection of Quinolone-Resistance by Structurally Unrelated Compounds |
A. DALHOFF1, A. HEISIG2, P. HEISIG2; |
1Bayer AG, Wuppertal, Germany, 2Univ. Hamburg,
Hamburg, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
014. Resistance Gene Clusters |
157. Identification of an Antibiotic Resistance Gene Cluster in
Pasteurella and Mannheimia |
C. KEHRENBERG, S. SCHWARZ; |
Inst. Animal Sci. and Animal Behaviour, Celle, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
015. Resistance to Inhibitors of Transcription and Translation |
164. Aminoglycoside-Streptothricin Resistance Genes in Enterococcus
faecium of Different Origins |
G. WERNER, W. WITTE; |
Robert Koch Inst., Wernigerode Branch, Wernigerode, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
017. Detection of ESBLs and Other ß-Lactamases |
184. The Importance of Extended-Spectrum ß-Lactamases (ESBL) Screening
Tests in Rapid Automated Antimicrobial Susceptibility Testing (AST) |
R. GROSS1, J. HOERLING1, U. EIGNER2, ANNE MARIE FAHR2; |
1University of Muenster,
Muenster, Germany, 2Laboratory Group, Heidelberg, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
018. Evaluation of Susceptibility Testing Methods |
192. Rapid Detection of Methicillin resistant Staphylococcus aureus
Isolates by an Nucleic Acid Based Hybridisation Assay |
S. SINGER, M. WEIZENEGGER, M. HENGSTLER, J. BARTEL, A. FAHR; |
Laboratory Group, Dept. of Microbiology, Heidelberg, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
021. Fungal Epidemiology |
259. Molecular Typing of Scedosporium apiospermum |
PETER M. RATH; |
Universität Essen, Institut für Medizinische Mikrobiologie,
Essen, Germany. |
|
Sunday, 11:00 a.m. - 12:30 noon |
021. Fungal Epidemiology |
272. The Role of Candida albicans Secreted Aspartic Proteinases in
Antibiotic-Associated Diarrhea |
R. KRAUSE1, E. SCHWAB1, F. DAXBÖCK1, G. J. KREJS1, E. C. REISINGER2, C. WENISCH1; |
1Division of Infectious
Diseases, Graz, Austria, 2Division of Infectious Diseases, Rostock, Germany. |
|
Sunday, 1:30 p.m. - 3:00 p.m. |
032. In Vitro Synergy Studies |
335. In Vitro Activity of the Beta-Lactamase Inhibitors Clavulanic Acid
(CLA), Sulbactam (SUL), and Tazobactam (TAZ) Alone or in Combination with
Beta-lactams against Epidemiologically Characterized Multi-Drug Resistant
Acinetobacter baumannii Strains |
H. SEIFERT, D. STEFANIK, H. WISPLINGHOFF; |
Institute of Medical Microbiology and Hygiene, Univ. of Cologne,
Cologne, Germany. |
|
Sunday, 1:30 p.m. - 3:00 p.m. |
034. Novel ß-Lactams and ß-Lactamase Inhibitors |
377. Mechanism of Action of New Siderophore Acylaminopenicillins |
U. MÖLLMANN1, L. HEINISCH1, D. ANKEL-FUCHS2, T. KÖHLER3; |
1Hans-Knöll-Inst., Jena,
Germany, 2Grünenthal GmbH, Aachen, Germany, 3University of
Geneva, Geneva, Switzerland. |
|
Sunday, 1:30 p.m. - 3:00 p.m. |
034. Novel ß-Lactams and ß-Lactamase Inhibitors |
378. Antibacterial Activity of New Siderophore Acylaminopenicillins |
U. MÖLLMANN1, L. HEINISCH1, A. BAUERNFEIND2, I. SCHNEIDER2, F. J. SCHMITZ3, D. ANKEL-FUCHS4; |
1Hans-Knöll-Inst., Jena,
Germany, 2MICOER Inst., Munich, Germany, 3University of Düsseldorf, Düsseldorf, Germany, 4Grünenthal GmbH,
Aachen, Germany. |
|
Sunday, 1:30 p.m. - 3:00 p.m. |
034. Novel ß-Lactams and ß-Lactamase Inhibitors |
382. AM-112, a Novel Oxapenem β-Lactamase Inhibitor with Unexpected
Synergistic Activity with Ceftazidime against Enterococci, Including Some
Vancomycin-Resistant Isolates |
CONOR E. JAMIESON1, P. A. LAMBERT1, R. HAKENBECK2, I. N. SIMPSON3; |
1Aston University, Birmingham,
United Kingdom, 2Universitat Kaiserslautern, Kaiserslautern, Germany, 3Micron Research,
Cambridge, United Kingdom. |
|
Sunday, 1:30 p.m. - 3:00 p.m. |
035. Pharmacoeconomics and Antibiotic Utilization |
389. Influence of an Infectious Disease Consulting Service on Quality and
Costs of Antibiotic Prescriptions at a University Hospital |
SEBASTIAN W. LEMMEN, A. BAUER, S.
KOTTERIK, H. NGYEN, C. BREUER, R. LÜTTICKEN, H. HEINTZ; |
Univ. Hosp. Aachen, Aachen, Germany. |
|
Sunday, 2:00 p.m. - 4:30 p.m. |
044. Hepatitis Viruses |
465. Detection of Hepatitis G Virus RNA and Antibodies to HGV in
Hemodialysis Children |
PAUL SCHNITZLER1, JULIA BERINGER1, MARKUS DASCHNER2, MAGDALENA GEISS1, HEIKE VON BAUM1; |
1Institute of Hygiene,
Heidelberg, Germany, 2Dept. of Pediatrics, Heidelberg, Germany. |
|
Sunday, 3:00 p.m. - 4:30 p.m. |
052. Novel Quinolones II |
557. The In Vitro Activity of Non-Fluorinated Quinolones against
Molecularly Characterized, Quinolone-Susceptible and -Resistant Isolates of
Staphylococcus aureus and Streptococcus pneumoniae |
M. E. JONES1, J. A. KARLOWSKY2, R. S. BLOSSER2, I. A. CRITCHLEY2, E. KARGINOVA2, F. J. SCHMITZ3, C. THORNSBERRY2, D. F. SAHM2; |
1Focus Technologies/MRL,
Hilversum, Netherlands, 2Focus Technologies/MRL, Herndon, VA, 3University Hospital,
Dusseldorf, Germany. |
|
Monday, 8:30 a.m. - 11:00 a.m. |
069. The Consequences of Antibiotic Resistance |
652. Attached Staphylococcus epidermidis Has Reduced Susceptibility
against Quinolones Independent from Biofilm Formation |
JOHANNES K. M. KNOBLOCH, H. VON OSTEN, D.
MACK; |
Institute of Medical Microbiology and Immunology, Hamburg,
Germany. |
|
Monday, 8:30 a.m. - 11:00 a.m. |
070. Respiratory Viruses |
663. Effectiveness of Oral Oseltamivir in Preventing Spread of
Influenza-Like Illness in Households with Proven Influenza |
R. B. BELSHE1, F. HAYDEN2, O. CAREWICZ3, R. LANNO4, C. MARTIN5, C. HUGHES6, P. WARD6; |
1Saint Louis University, St
Louis, MO, 2University of Virginia, Charlottesville, VA, 3General Practice,
Dossenheim, Germany, 4Merealahe Family Doctors Practice, Tallinn, Estonia, 5Roche Global
Development, Basel, Switzerland, 6Roche Global Development, Welwyn, United Kingdom. |
|
Monday, 8:30 a.m. - 11:00 a.m. |
071. HIV Session I |
671. Switch to Trizivir Versus Continued HAART Provides Equivalent HIV-1
RNA Suppression at 48 weeks (TRIZAL - AZL30002) |
C. KATLAMA1, S. FENSKE2, B. GAZZARD3, A. LAZZARIN4, L. BEAUVAIS5; |
1Hôpital Pitié-Salpêtrière,
Paris, France, 2HIV-Schwerpunktpraxis, Hamburg, Germany, 3Chelsea and
Westminster Hosp., London, United Kingdom, 4San Raffaele Scientific Institute, Milan, Italy, 5GlaxoSmithKline,
Marly le Roi, France. |
|
Monday, 8:30 a.m. - 11:00 a.m. |
072. Clinical Mycology |
681. Itraconazole for Antifungal Prophylaxis in Neutropenic Patients: a
Meta-Analysis of 2181 Patients |
A. GLASMACHER1, C. HAHN1, E. MOLITOR2, G. MARKLEIN2, I. SCHMIDT-WOLF1; |
1Dpt. of Internal Medicine I,
Univ. of Bonn, Bonn, Germany, 2Inst. of Med. Microbiology and Immunology, Univ. of Bonn,
Bonn, Germany. |
|
Monday, 9:30 a.m. - 11:00 a.m. |
073. Antimicrobial Resistance of Respiratory Pathogens |
685. Prevalence of Antibiotic Resistance among European Respiratory Tract
Pathogens (1999/2000) |
D. FELMINGHAM1, R. R. REINERT2; |
1GR Micro, London, United
Kingdom, 2Natl. Reference Ctr. for Streptococci, Aachen, Germany. |
|
Monday, 9:30 a.m. - 11:00 a.m. |
073. Antimicrobial Resistance of Respiratory Pathogens |
692. Worldwide Surveillance of Antibiotic Resistance among Clinical
Isolates of Streptococcus pneumoniae and Streptococcus pyogenes during
1999/2000 |
R. R. REINERT1, D. J. HOBAN2, D. FELMINGHAM3, J. PLUIM4; |
1Natl. Reference Ctr. for
Streptococci, Aachen, Germany, 2Health Sciences Ctr., Winnipeg, Canada, 3GR Micro, London,
United Kingdom, 4Aventis Pharma, Bridgewater, NJ. |
|
Monday, 9:30 a.m. - 11:00 a.m. |
073. Antimicrobial Resistance of Respiratory Pathogens |
693. Antibiotic Resistance of Streptococcus pyogenes and Streptococcus
pneumoniae Strains Isolated from RTI of Outpatients in Germany, 2000-2001 |
R. R. REINERT, R. LUETTICKEN, C. BRIEFS, N. NEUBERGER, M.
LEMPERLE, A. AL-LAHHAM; |
National Reference Center for Streptococci, Aachen, Germany. |
|
Monday, 9:30 a.m. - 11:00 a.m. |
079. Infections in Neutropenic Patients |
775. Three-Armed Multicenter Randomized Study on the Empiric Treatment of
Neutropenic Fever in a High Risk Patient Population (PEG Study III) |
OLIVER A. CORNELY1, D. REICHERT2, D. BUCHHEIDT3, G. MASCHMEYER4, M. WILHELM5, X. SCHIEL6, B. GLAß7, G. FÄTKENHEUER1, H. LINK8, M. HELMERKING9, D. ADAM10, W. HIDDEMANN6, FOR THE PAUL-EHRLICH-GESELLSCHAFT (PEG); |
1Univ Hosp, Koeln, Germany, 2Städtische Kliniken,
Oldenburg, Germany, 3Univ Hosp, Mannheim, Germany, 4Charité, Berlin, Germany, 5Univ Hosp, Würzburg, Germany, 6Univ Hosp, Med Clin III, Munich, Germany, 7Univ Hosp, Kiel,
Germany, 8Westpfalz-Klinikum, Kaiserslautern, Germany, 9Algora CRO, Munich,
Germany, 10von Haunersches Kinderspital, Univ Munich, Munich, Germany. |
|
Monday, 9:30 a.m. - 11:00 a.m. |
079. Infections in Neutropenic Patients |
779. Reduction of Central Venous Catheter-Related Infection (CRI) in
Cancer Patients with Severe Neutropenia: A Prospective Controlled Randomized
Trial Using a Chlorhexidine and Silver-Sulfadiazine Impregnated Central
Venous Line (CH-SS) |
S. ZENZ1, H. RUSCHULTE1, A. OSTHAUS1, J. HEINE1, B. JUETTNER1, G. HEIL2, K. JAEGER1, M. KARTHAUS3; |
1Dept. Anesthesiology Hannover
Med. Sch., Hannover, Germany, 2Dept. Hematology Hannover Med. Sch., Hannover, Germany, 3Ev. Johannes
Krankenhaus, Bielefeld, Germany. |
|
Monday, 11:00 a.m. - 12:30 noon |
080. Endocarditis and Vascular Infections |
782. Expression of Staphylococcus aureus Fibronectin-Binding Protein A
(FnBPA) Mediates Bacterial Internalization by Endothelial Cells In Vitro and
in Rats with Experimental Endocarditis (EE) |
YOK-AI QUE1, J-A HAEFLIGER1, P. FRANCOIS2, S. PIU1, B. SINHA3, J-M ENTENZA1, J. VOUILLAMOZ1, M. HERRMANN3, P. VAUDAUX2, P. MOREILLON1; |
1CHUV, Lausanne, Switzerland, 2HCUGE, Geneva,
Switzerland, 3Medical Microbiology, Muenster, Germany. |
|
Monday, 11:00 a.m. - 12:30 noon |
081. Carbapenems In Vitro |
793. In Vitro Activity of Faropenem against Pediatric Isolates |
D. ADAM; |
Klinikum Innenstadt der LMU, Munich, Germany. |
|
Monday, 11:00 a.m. - 12:30 noon |
081. Carbapenems In Vitro |
795. In Vitro Activity of Faropenem (FAR) against Genetically
Characterized Isolates of Moraxella catarrhalis and Streptococcus pneumoniae |
F. J. SCHMITZ1, M. BOOS1, S. MAYER1, J. VERHOEF2, D. MILATOVIC2, A. C. FLUIT2; |
1Univ. Hosp. Dusseldorf,
Dusseldorf, Germany, 2Univ. Hosp Utrecht, Utrecht, Netherlands Antilles. |
|
Monday, 11:00 a.m. - 12:30 noon |
081. Carbapenems In Vitro |
798. Anti-Staphylococcal Activity of Faropenem |
C. VON EIFF, S. SCHEPERS, G. PETERS; |
Univ. Münster Hosp. and Clinics, Munster, Germany. |
|
Monday, 11:00 a.m. - 12:30 noon |
083. Clinical Mycology |
833. Systemic Fungal Infections in Preterm and Term Infants in Germany |
A. H. GROLL1, S. ELSTNER2, R. SCHLOESSER3, FRANK-MICHAEL MÜLLER2, R. ROOS4; |
1Pediatric Oncology Branch,
NCI, Bethesda, MD, 2Dept. of Pediatrics, Würzburg, Germany, 3Dept. of Pediatrics,
Frankfurt, Germany, 4Children's Hospital Harlaching, München, Germany. |
|
Monday, 11:00 a.m. - 12:30 noon |
084. Fungal Diagnosis |
839. Development and Evaluation of the Nuclisens Basic Kit NASBA for the
Detection of RNA from Yeast Frequently Resistant to Antifungal Drugs |
JUERGEN H. LOEFFLER, C. DORN, H. HEBART,
P. COX, S. MAGGA, H. EINSELE; |
Medizinische Klinik, Tuebingen, Germany. |
|
Monday, 11:00 a.m. - 12:30 noon |
084. Fungal Diagnosis |
840. Specific Detection of Genomic Fungal DNA from Clinically Relevant
Yeast and Moulds Using the Pyrosequencing Technology |
JUERGEN H. LOEFFLER1, B. GHARIZADEH2, E. NORBERG3, S. GALAL3, L. KLINGSPOR3, J. TOLLEMAR3, H. EINSELE1, P. NYREN2; |
1Medizinische Klinik,
Tuebingen, Germany, 2Royal Institute of Technology, Stockholm, Sweden, 3Huddinge University
Hospital, Huddinge, Sweden. |
|
Monday, 11:00 a.m. - 12:30 noon |
085. Community-Acquired Pneumonia |
863. Clinical and Outcomes Assessment of the Management of
Community-Acquired Pneumonia (CAP): a Comparison of Moxifloxacin to Standard
First-Line Oral Monotherapy or Combination Regimen |
G. HÖFFKEN1, P. A. CORRIS2, J. S. MUIR3, P. P. SAGNIER4, I. DUPRAT-LOMON44, R. KUBIN5, A. TORRES6; |
1Universitätsklinikum, Dresden,
Germany, 2Freeman Hospital, Newcastle, United Kingdom, 3Hôpital
BoisGuillaume, Rouen, France, 4Bayer PLC, Slough, United Kingdom, 5Bayer AG, Wuppertal,
Germany, 6Institute Clinic de Malalties Respiratories, Barcelona,
Spain. |
|
Monday, 11:00 a.m. - 12:30 noon |
085. Community-Acquired Pneumonia |
864. Superior Outcomes with Moxifloxacin IV/PO Monotherapy Compared to
IV/PO Amoxicillin/Clavulanate ± Clarithromycin in the Treatment of
Community-Acquired Pneumonia (CAP) |
M. DRUMMOND1, R. FINCH2, I. DUPRAT-LOMON3, P. P. SAGNIER3, O. COLLINS4, R. KUBIN5; |
1University of York, York,
United Kingdom, 2The City Hospital, Nottingham, United Kingdom, 3Bayer plc, Slough,
United Kingdom, 4Bayer plc, Newbury, United Kingdom, 5Bayer AG, Wuppertal,
Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
097. Human Pharmacokinetics of Antimicrobials |
940. Effect of Multiple Dose Treatments with Faropenem Daloxate in
Comparison to Amoxicillin / Clavulanic Acid on the Normal Fecal and
Oropharyngeal Flora of Healthy Subjects |
J. NAGELSCHMITZ1, M. KOCH2, W. R. HEIZMANN2, C. KRASEMANN1, B. U. VOIGHT1, J. KUHLMANN1, G. WENSING1; |
1Bayer AG, Wuppertal, Germany, 2Labor Wagner &
Partner, Gottingen, Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
097. Human Pharmacokinetics of Antimicrobials |
943. Absorption of Faropenem Daloxate Delivered Locally to Different Sites
of the Gastrointestinal Tract (GIT) by an Enterion Capsule |
B. VOITH1, I. WILDING2, A. WRAY2, A. CONNOR2, U. VOIGT1, J. NAGELSCHMITZ1, J. KUHLMANN1; |
1Inst. of Clin. Pharmacology,
Bayer AG, Wuppertal, Germany, 2Pharmaceutical Profiles, Nottingham, United Kingdom. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
097. Human Pharmacokinetics of Antimicrobials |
944. No Evidence of Active Metabolites of Faropenem |
A. SCHMIDT, B. VOITH, A. DALHOFF; |
Bayer AG, Wuppertal, Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
097. Human Pharmacokinetics of Antimicrobials |
946. Tissue Penetration of Cefditoren (CEE) into Bronchial Mucosa (BM) and
Epithelial Lining Fluid (ELF) in Patients Undergoing Fiberoptic Bronchoscopy |
M. KINZIG-SCHIPPERS1, M. HINDER2, K. GÖHLER2, U. LOOS3, F. VOGEL4, F. SORGEL1; |
1IBMP, Nürnberg, Germany, 2Grünenthal GmbH,
Aachen, Germany, 3Knappschaft Hosp., Recklinghausen, Germany, 4Hosp. Internal
Medicine, Hofheim a. T., Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
098. Microbial Virulence Factors |
953. Importance of Sortase in a Staphylococcus aureus Foreign Body
Infection Model |
M. E. RUPP1, P. D. FEY1, W. GILES1, S. H. HINRICHS1, G. THUMM2, F. GOTZ2; |
1Univ of Nebraska Med Ctr,
Omaha, NE, 2Univ of Tubingen, Tubingen, Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
098. Microbial Virulence Factors |
969. Electroporation of DNA Sequences from the Pathogenicity Locus (PaLoc)
of Toxigenic Clostridium difficile into a Nontoxigenic Strain |
G. ACKERMANN1,2, Y. J. TANG1, J. P. HENDERSON1, A. C. RODLOFF2, J. SILVA JR.1, S. H. COHEN1; |
1University of California,
Davis, Sacramento, CA, 2University of Leipzig, Leipzig, Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
098. Microbial Virulence Factors |
970. One -Step Cloning and Expression of Clostridium difficile Toxin B
Gene (tcdB) |
Y. J. TANG1, G. ACKERMANN1,2, J. P. HENDERSON1, J. SILVA, JR.1, S. H. COHEN1; |
1University of California,
Davis, Sacramento, CA, 2University of Leipzig, Leipzig, Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
100. Ketolide Susceptibility Studies |
1001. Comparative In Vitro Activity of ABT-773 and Two Macrolides against
Staphylococci |
C. VON EIFF, G. PETERS; |
Inst. of Med. Microbiol., Univ. of Münster, Hosp. and Clin.,
Münster, Germany. |
|
Monday, 1:30 p.m. - 3:00 p.m. |
100. Ketolide Susceptibility Studies |
1007. In Vitro Activity of ABT-773 and Six Other Antibacterial Agents
against Recent Community-Acquired Respiratory Tract Isolates: a German
Multicenter Study |
S. BAGEL, J. BRAUERS, M. KRESKEN; |
Antiinfectives Intelligence, Bonn, Germany. |
|
Monday, 2:00 p.m. - 4:30 p.m. |
105. Multiple Pathways to Glycopeptide Resistance in Staphylococci |
1069. Role of Teichoic Acid Structure In Susceptibility to Glycopeptide
Antibiotics |
ANDREAS PESCHEL; |
Univ. Tuebingen, Tuebingen, Germany. |
|
Monday, 3:00 p.m. - 4:30 p.m. |
121. Infection Control and Hospital Epidemiology |
1208. Plasma Sterilization: Efficacy of the New STERRAD 200 Tested in the
Hospital Setting |
A. F. WIDMER1, J. OKPARA2, R. FREI1, B. JAUSSI1, M. BORNEFF2; |
1University Hospitals, Basel,
Switzerland, 2Martin Luther University, Halle, Germany. |
|
Monday, 2:00 p.m. - 4:30 p.m. |
112. Sepsis |
1107. Mutations of Toll-Like Receptor (TLR) 4 are Associated withIncidence
and Severity of Sepsis in Critically Ill Patients |
R. R. SCHUMANN1, E. LORENZ2, E. LATZ3, N. LIMMER1, P. M. SCHLAG3, D. A. SCHWARTZ2; |
1Inst. f. Microbiology, Charité
Medical Center, Berlin, Germany, 2Duke University Medical Center, Durham, NC, 3Department of
Surgery and Surgical Oncology, Robert-Rössle-Klinik, Charité Medical Center,
Berlin, Germany. |
|
Monday, 3:00 p.m. - 4:30 p.m. |
123. Nosocomial Infections II: Clostridium difficile |
1234. Association between Antecedent Use of Fluoroquinolones and
Resistance to Moxifloxacin (MXF) in Clostridium difficile |
GRIT ACKERMANN1,2, Y. J. TANG1, R. SCHAUMANN2, J. P. HENDERSON1, A. C. RODLOFF2, J. SILVA, JR.1, S. H. COHEN1; |
1University of California,
Davis, Sacramento, CA, 2University of Leipzig, Leipzig, Germany. |
|
Monday, 3:00 p.m. - 4:30 p.m. |
125. Nosocomial Infections in Immunosuppressed Hosts |
1251. Oral Flora and Mucositis Grade During Myeloablative Chemotherapy |
H. LOEVENICH1, C. KEULERTZ1, H. SCHUETT-GEROWITT2, U. BETHE1, D. SOEHNGEN1, D. WALDSCHMIDT1, O. A. CORNELY1; |
1University of Cologne, Dept.
of Internal Med., Cologne, Germany, 2University of Cologne, Inst. of Microbiol., Cologne, Germany. |
|
Tuesday, 8:30 a.m. - 11:00 a.m. |
141. Surveillance and Mechanisms of Macrolide Resistance |
1320. The Recently Identified Gene, msrC, Is Not Equally Distributed among
Enterococcus faecium of Different Ecological Origins |
G. WERNER, W. WITTE; |
Robert Koch Inst., Wernigerode Branch, Wernigerode, Germany. |
|
Tuesday, 8:30 a.m. - 11:00 a.m. |
143. Hand Hygiene at Last? |
1338. Limited Efficacy of Alcohol-Based Hand Gels for Hand Antisepsis |
D. PITTET1, P. RUDOLPH2, A. KRAMER2; |
1University of Geneva
Hospitals, Geneva, Switzerland, 2Univ. of Greifswald, Greifswald, Germany. |
|
Tuesday, 9:30 a.m. - 11:00 a.m. |
149. Linezolid In Vitro |
1423. In Vitro Activity of Linezolid, Eperezolid,
Quinupristin/Dalfopristin, and the new Glycopeptide LY 333328 against
Enterococci Recovered from Intensive Care Units and Hematology-Oncology Wards
of a German University Hospital |
FRIEDRICH B. SPENCKER, K. GRESENS, A. C.
RODLOFF; |
Institute of Medical Microbiology and Epidemiology of Infection,
Univ. of Leipzig, Leipzig, Germany. |
|
Tuesday, 9:30 a.m. - 11:00 a.m. |
150. Nosocomial Bloodstream Infections |
1434. Incidence of Central Venous Catheter(CVC)-Associated Bloodstream
Infections in Patients with Febrile Neutropenia Treated for Acute Leukemia
(AL) |
M. KARTHAUS1, T. DOELLMANN2, S. WEBER3, G. HEIL2, A. GANSER2; |
1Ev. Johannes Krankenhaus,
Bielefeld, Germany, 2Dept. Hematology, Hannover Med. Sch., Hannover, Germany, 3Dept. Microbiology,
Hannover Med. Sch., Hannover, Germany. |
|
Tuesday, 9:30 a.m. - 11:00 a.m. |
153. Nosocomial Infections VI: Surgical Site and Prosthetic Device
Infections |
1454. Deep Sternal Wound Infection Following Cardiac Surgery -
Epidemiology and Treatment |
D. V. SCHMITT1, M. C. CLAROS2, J. F. GUMMERT1, A. C. RODLOFF2, F. W. MOHR1; |
1Department of Cardiac Surgery,
University of Leipzig, Leipzig, Germany, 2Institute of Medical Microbiology, University of Leipzig,
Leipzig, Germany. |
|
Tuesday, 9:30 a.m. - 11:00 a.m. |
154. Utilization of Antibiotics in the Intensive Care Unit |
1465. Transmission of Nosocomial Pathogens in Five Intensive Care Units
(ICU) in a German University Hospital |
K. BECK-BEILECKE, P. GASTMEIER, H. RÜDEN,
MEMBERS OF SIR3 RESEARCH GROUP; |
Inst. of Hygiene, Free Univ./ Dept. of Hospital Hygiene,
Charité, Berlin, Germany. |
|
Tuesday, 11:00 a.m. - 12:30 noon |
157. ß-Lactamases: Bla, Bla, Bla... |
1500. Aeromonas veronii bv. Sobria Beta-Lactamase Induction isLinked to
Disruption of Cell-Wall Metabolism |
M. B. AVISON1, K. WESTPHAL2, P. NIUMSUP1, T. R. WALSH1, A. P. MACGOWAN1, B. WIEDEMANN2, P. M. BENNETT1; |
1University of Bristol,
Bristol, United Kingdom, 2University of Bonn, Bonn, Germany. |
|
Tuesday, 11:00 a.m. - 12:30 noon |
160. Pediatric Infectious Disease II |
1539. A Prospective Randomized Trial Comparing the Efficacy and Safety of
Piperacillin/Tazobactam Versus Piperacillin/Tazobactam Plus Netilmicin in the
Treatment of Febrile Neutropenia in Allogeneic Stem Cell Recipients |
MICHAEL G. KIEHL, M. BISCHOFF, N. BASARA, S. GUENZELMANN, A. A. FAUSER; |
Clinic of Bone Marrow Transplantation and Hematology/Oncology,
Idar-Oberstein, Germany. |
|
Tuesday, 11:00 a.m. - 12:30 noon |
161. Vaccine Trials |
1560. Cellular Immune Response to Varicella in Healthy Subjects 12 to 22
Months Old Receiving either a Combined Measles-Mumps-Rubella-Varicella
Vaccine or Separate Measles-Mumps-Rubella and Varicella Vaccines |
F. ZEPP1, C. U. MEYER1, P. HABERMEHL1, M. KOUTSOUKOS2, J. M. STEENS2, F. BECKERS2; |
1Johannes Gutenberg
Universitat, Mainz, Germany, 2GlaxoSmithKline, Rixensart, Belgium. |
|
Tuesday, 11:00 a.m. - 12:30 noon |
164. Clinical Candidiasis and Aspergillosis |
1624. A Double-Blind Study of Fluconazole Oral Suspension vs.Capsules in
the Treatment of Oropharyngeal Candidiasis in HIV-Patients |
M. EICHEL1, C. SCHNEIDER2, G. JUST-NUEBLING2; |
1University Hospital,
Frankfurt/Main, Germany, 2university hospital, Frankfurt/Main, Germany. |
|
Tuesday, 12:00 noon - 1:50 p.m. |
164b. Viruses, Fungi and Bacterial Pathogenesis |
LB-14. AXD455 – A Novel Inhibitor of Antiretroviral Drug-Resistant HIV by
Pharmacological Interference With Nuclear Export of Viral mRNA. |
D. Bevec1, i. HAUBER2, f. KRÄTZER1, c. WALLASCH1, f. HORN2, h. WALTER2, t. HARRER2, j. HAUBER2, u. ELBEN1; |
1Axxima Pharmaceuticals AG,
Martinsried, GERMANY, 2Univ. Erlangen-Nürnberg, Erlangen, GERMANY. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
171. Animal Models |
1662. Effects of BMS 284,756, Ofloxacin and Ciprofloxacin on the
Ultrastructure of Achilles Tendon in Juvenile Rats |
MEHDI SHAKIBAEI1, E. M. KAPPEL2, S. FASSHEBER2, I.
BAUMANN-WILSCHKE2, R. STAHLMANN2; |
1Institut of Anatomy, Berlin,
Germany, 2Institute of Clinical Pharmacology and Toxicology, Berlin,
Germany. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
172. Novel Antivirals |
1664. BAY 41-4109: A Novel Non-Nucleosidic and Highly Potent Inhibitor of
Human Hepatitis B Virus. Part 1: Synthesis and Structure Activity
Relationship (SAR) |
SIEGFRIED GOLDMANN, J. STOLTEFUSS, U.
NIEWOEHNER, T. KRAEMER, E. GRAEF, K. DERES, R. N. A. MASANTSCHEK, O. WEBER,
D. KOLETZKI, A. PAESSENS; |
Bayer AG, Wuppertal, Germany. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
172. Novel Antivirals |
1665. BAY 41-4109: A Novel Non-Nucleosidic and Highly Potent Inhibitor of
Human Hepatitis B Virus (HBV). Part 2: In Vitro Profile |
A. PAESSENS1, E. GRAEF2, K. DERES2, S. GOLDMANN2, U. NIEWOEHNER2, J. STOLTEFUSS2, D. HAEBICH2, H. RUEBSAMEN-WAIGMANN2, D. KOLETZKI2, R.N.A. MASANTSCHEK2, W.S. MASON3, C.H. SCHROEDER4, O. WEBER2; |
1Bayer AG, Wuppertal, Germany, 2BAYER AG, Wuppertal,
Germany, 3Fox Chase Center, Philadelphia, PA, 4German Cancer
Research Center, Heidelberg, Germany. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
172. Novel Antivirals |
1666. BAY 41-4109: A Novel Non-Nucleosidic and Highly Potent Inhibitor of
Human Hepatitis B Virus. Part 3: In Vivo Profile |
OLAF WEBER1, K.-H. SCHLEMMER2, E. GRAEF2, K. DERES2, S. GOLDMANN2, U. NIEWOEHNER2, J. STOLTEFUSS2, D. HAEBICH2, E. HARTMANN2, H. RUEBSAMEN-WAIGMANN2, A. PAESSENS2; |
1Bayer AG, West Haven, CT, 2Bayer AG, Wuppertal,
Germany. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
172. Novel Antivirals |
1667. BAY 41-4109: a Novel Non-Nucleosidic and Highly Potent Inhibitor of
Human Hepatitis B Virus Induces HBV Core Protein Depletion: Part 4 |
K. DERES1, C. H. SCHROEDER2, U. PLEISS3, E. GRAEF3, S. GOLDMANN3, U. NIEWOEHNER3, J. STOLTEFUSS3, O. WEBER3, D. KOLETZKI3, R. MASANTSCHEK3, A. PAESSENS3, D. HAEBICH3, H. RUEBSAMEN-WAIGMANN3; |
1Bayer AG, Wuppertal, Germany, 2DKFZ, Heidelberg,
Germany, 3BAYER AG, Wuppertal, Germany. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
175. Antiretroviral Agents: Adherence, Pharmacokinetics, and
Pharmacodynamics |
1741. Longterm Pharmacokinetics (PK) of Amprenavir (APV) in Combination
with Ritonavir (RTV) or Delavirdine (DLV) in HIV-Infected Children |
UWE H. P. WINTERGERST, M. KUROWSKI, C. ENGELHORN, F. HOFFMANN,
S. URSCHEL, G. NOTHEIS, B. H. BELOHRADSKY; |
University Children's Hospital, Munich, Germany. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
176. Antiretroviral Resistance |
1745. Evaluation of an Open Expert-Based Genotype Interpretation Program:
RetroGram |
A.M BEEN-TIKTAK1, K. KORN2, W. KEULEN1,3, E. SCHWINGEL2, H. WALTER2, B. SCHMIDT2, H. STIRNADEL4, J. SCHAPIRO5, C. BOUCHER3; |
1Virology Networks, Utrecht,
Netherlands, 2Institute of Clinical and Molecular Virology, University of
Erlangen-Nurnberg, Erlangen, Germany, 3University Medical Center, Utrecht, Netherlands, 4Roche Discovery,
Welwyn, United Kingdom, 5Stanford University, Stanford, CA. |
|
Tuesday, 1:30 p.m. - 3:00 p.m. |
176. Antiretroviral Resistance |
1758. M184V Independent Resistance to Abacavir Detected by HIV Phenotypic
Assay |
THOMAS E. O. FENNER1, N. WIESE1, H. MUELLER1, U. SCHMITZ2, H. PETERSEN3; |
1Laboratory Dres Fenner,
Hamburg, Germany, 2City Laboratory, Hamburg, Germany, 3Fen-Lab, Hamburg,
Germany. |
|
Tuesday, 2:00 p.m. - 4:30 p.m. |
184. Resistance by Ribosome Alteration |
1813. High-Level Ketolide-Resistant Streptococci |
A. G. TAIT-KAMRADT1, R. R. REINERT2, A. AL-LAHHAM2, D. E. LOW3, J. A. SUTCLIFFE1; |
1Pfizer Global Res. and Dev.,
Groton, CT, 2Natl. Reference Ctr. For Streptococci, Aachen, Germany, 3Mount Sinai Hosp.,
Toronto, ON, Canada. |
|
Tuesday, 2:00 p.m. - 4:30 p.m. |
185. Pediatric Infectious Diseases |
1826. Short Course Antibiotic Therapy of Streptococcal Pharyngitis:
Comparison of Clarithromycin with Amoxicillin/Clavulanate and Cefuroxime
Axetil |
D. ADAM1, H. SCHOLZ2, H. HAVERKAMP3, M. HELMERKING3; |
1Dept. of Antimicrobial
Therapy, Dr. v. Haunersches Children's Hosp., Univ. of Munich, Munich,
Germany, 2Inst. for Infectiology, Microbiol. and Hygienics, Municipal
Hosp. Buch, Berlin, Germany, 3Algora Clin. Res. Organization, Munich, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
189. Meningitis |
1856. Regulation of Caspases in Experimental Pneumococcal Meningitis |
MATTHIAS H. P. V. MERING, T. KAMBACH, J.
GERBER, U. MICHEL, S. BUNKOWSKI, R. NAU; |
University Hospital of the Georg-August-University Goettingen,
Goettingen, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
189. Meningitis |
1858. Combining Antiinflammatory and Antioxidative Therapy in Experimental
Meningitis Had No Beneficial Effect on Mortality and Spatial Memory |
J. GERBER, C. BOLLINGER, R. NAU; |
Georg-August-University, Goettingen, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
190. Antimicrobial Use and Resistance |
1866. Clinafloxacin, Linezolid and Telithromycin Can Select for Resistant
Bacteria in the Human Intestinal Microflora |
C. EDLUND1, H. LODE2, C.E. NORD1; |
1Karolinska Institute,
Stockholm, Sweden, 2Hospital Zehlendorf/Heckeshorn, Berlin, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
192. Herpesviruses |
1885. Comparison of Two Different Real-Time PCR Assays and the COBAS
Amplicor CMV Monitor for the Detection of Cytomegalovirus-DNA in Patients
after Allogeneic Bone Marrow Transplantation |
JUERGEN H. LOEFFLER, H. HEBART, E.
SZENTGYOERGYI, H. EINSELE; |
Medizinische Klinik, Tuebingen, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
192. Herpesviruses |
1885. Comparison of Two Different Real-Time PCR Assays and the COBAS
Amplicor CMV Monitor for the Detection of Cytomegalovirus-DNA in Patients
after Allogeneic Bone Marrow Transplantation |
JUERGEN H. LOEFFLER, H. HEBART, E.
SZENTGYOERGYI, H. EINSELE; |
Medizinische Klinik, Tuebingen, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
193. Antiretroviral Therapy I |
1907. Enhancement of HIV-Specific Immune Response during Structured
Treatment Interruptions (STIs) in Chronic Infection Depends on Baseline Viral
Load |
C. HOFFMANN1, W. MAYER2, E. WOLF1, M. SOVRIC1, E. GERSBACHER1, R. VON BAEHR2, F. W. TILLER3, E. JAEGEL-GUEDES1, H. JAEGER1, W. BIEGER3; |
1KIS - Curatorium for
Immunedeficiency, Munich, Germany, 2Alphagen GmbH, Munich, Germany, 3Immunological Laboratories, Munich, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
193. Antiretroviral Therapy I |
1910. Long-Term Effects of Treatment Interruptions: 18-Month Evaluation of
a Controlled Trial in > 300 HIV+ Patients |
E. WOLF1, E. GERSBACHER1, J. SCHARDT1, S. MUELLER1, C. HOFFMANN2, M. PROCACCIANTI3, F. MOSTHAF3, A. ULMER4, E. JAEGEL-GUEDES2, H. JAEGER2; |
1MUC Research GmbH, Munich,
Germany, 2KIS - Curatorium for Immunedeficiency, Munich, Germany, 3Private Practice,
Karlsruhe, Germany, 4Private Practice, Stuttgart, Germany. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
193. Antiretroviral Therapy I |
1915. The Stability of the Viral Load in Subjects with Virological Failure
who Remain on the Same HAART Regimen: The EuroSIDA Study |
J. D. LUNDGREN1, A. COZZI-LEPRI2, V. MILLER3, B. LEDERGERBER4, S. VELLA5, J. WEBER6, J. N. BRUUN7, O. KIRK1, B. CLOTET8, A. PHILIPS2; |
1EuroSIDA Coordinating Centre,
Hvidovre, Denmark, 2Royal Free Hospital, London, United Kingdom, 3J W Goethe,
Frankfurt, Germany, 4Univ Hosp, Zürich, Switzerland, 5Inst Superiore, Rome, Italy, 6St Mary's Hosp, London, United Kingdom, 7Ullevaal Hosp, Oslo,
Norway, 8HUiGTiP, Barcelona, Spain. |
|
Tuesday, 3:00 p.m. - 4:30 p.m. |
194. Antiretroviral Therapy II |
1925. Kaletra (lopinavir/ritonavir) and Efavirenz: 72 Week Safety/Efficacy
Evaluation andPhenotypic/Genotypic Breakpoints in Multiple PI Experienced
Patients |
S. DANNER1, S. BRUN2, J. SYLTE2, J. ISAACSON2, A. LAZZARIN3, P. M. GIRARD4, J. ROCKSTROH5, S. BECKER6, G. PANTALEO7, F. BERGMANN8, N. CLUMECK9, D. HO10, R. TUBIANA11, G. CAROSI12, R. BERTZ2, A. HSU2, M. KING2, B. RICHARDS2, D. KEMPF2, E. SUN2; |
1Academic Med. Ctr. Amsterdam,
Amsterdam, Netherlands, 2Abbott Laboratories, Abbott Park, IL, 3Osp. S. Raffaele,
Milano, Italy, 4H. Rothschild, Paris, France, 5Med. Klinik der Uni. Bonn, Bonn, Germany, 6Pacific Horizons
Med. Grp., San Francisco, CA, 7H. de Beaumont, Lausanne, Switzerland, 8Charite Humboldt-U.
Berlin, Berlin, Germany, 9CHU Saint-Pierre-Brussels, Brussels, Belgium, 10Aaron Diamond, New
York, NY, 11H. Pitie-Salpetriere, Paris, France, 12U. of Brescia,
Brescia, Italy. |
|
Wednesday, 8:30 a.m. - 11:30 a.m. |
212. Pneumococcal Vaccines |
2038. Immunization of Mice with the Cell Wall-Associated Serine Protease
PrtA of Streptococcus pneumoniae Protects against Invasive Pneumococcal
Infection |
I. AZEH1, R. NAU1, G. BETHE2, A. NEUHAUS2, A. WELLMER1, H. P. HEINZ2, G. ZYSK2; |
1Neurology, Univ. Hosp.,
Goettingen, Germany, 2Med. Microbiol., Univ., Duesseldorf, Germany. |
|
Wednesday, 8:30 a.m. - 11:00 a.m. |
213. Bloodstream and Vascular Catheter Infections: Progress! |
2044. Catheter-Related Bloodstream-Infection (CRBSI) in Neutropenic Cancer
Patients Determined by Quantitative Blood Cultures (QBC), Differential Time
to Positivity (DTP), and Molecular Epidemiologic Typing with PFGE |
HARALD SEIFERT1, K. SEGGEWISS1, M. DECKER1, H. WISPLINGHOFF1, H. LOEVENICH2, O. CORNELY2, G. FÄTKENHEUER2; |
1Institute of Medical
Microbiology, Immunology and Hygiene, Cologne, Germany, 2Department for
Internal Medicine, University of Cologne, Cologne, Germany. |
|
Wednesday, 8:30 a.m. - 11:00 a.m. |
215. Guidelines: Is the Juice Worth the Squeeze? |
2063. A Decision Support System (DSS) for Antibiotic Treatment Improves
Empirical Treatment and Reduces Costs |
B. KRISTENSEN1, S. LARSEN2, H. C. SCHOENHEYDER1, L. LEIBOVICI3, M. PAUL3, U. FRANK4, S. ANDREASSEN2; |
1Aalborg Hosp, Aalborg,
Denmark, 2Aalborg Univ, Aalborg, Denmark, 3Rabin Med Ctr, Petah Tiqva, Israel, 4Freiburg Univ Hosp,
Freiburg, Germany. |
|
Wednesday, 8:30 a.m. - 10:00 a.m. |
216. Pharmacodynamics of Antimicrobials I: In Vitro Models |
2078. Influence of Sucrose and Human Serum on the Activity of Faropenem
and Amoxicillin against Streptococcus pneumoniae |
S. SCHUBERT1, U. ULLMANN1, A. DALHOFF2; |
1Dept. Med. Microbiol., Univ.
Hosp. Kiel, Kiel, Germany, 2Bayer AG, Wuppertal, Germany. |
|
Wednesday, 8:30 a.m. - 10:00 a.m. |
220. Novel Antibacterials III: Screens, Targets and Technologies |
2124. Isoprenoid Biosynthesis as a Novel Antibacterial Target |
A. JACOBI1, H. BAUM1, T. NAKANO2, R. R. ANNAND2, S. ANDERSON2, J. BREUNIG2, S. BOWES2, P. GOLDENBLATT2, S. S. ASHRAF3, H. GRØN3, P. HAMILTON3, D. J. CHRISTENSEN3, H. LOFERER1; |
1GPC Biotech AG, Munich,
Germany, 2GPC Biotech Inc., Cambridge, MA, 3Karo Bio USA,
Durham, NC. |
|
Wednesday, 8:30 a.m. - 10:00 a.m. |
220. Novel Antibacterials III: Screens, Targets and Technologies |
2132. Peptide Surrogate Ligands in Antimicrobial Drug Discovery for
Targets of Unknown Function |
S. S. ASHRAF1, H. GRØN1, E. ANDERSON1, A. MCNAMARA1, S. LLOYD1, D. DUFFIN1, A. JACOBI2, T. NAKANO3, R. R. ANNAND3, H. LOFERER2, D. J. CHRISTENSEN1, P. HAMILTON1; |
1Karo Bio USA, Durham, NC, 2GPC Biotech AG,
Munich, Germany, 3GPC Biotech Inc., Cambridge, MA. |
|
Wednesday, 8:30 a.m. - 10:00 a.m. |
221. Novel Antifungals and Antiparasitics |
2144. PLD-118, a Novel Antifungal for Treatment of Yeast Infections: In
Vivo Efficacy in Candida albicans Infection in Mice and Rats |
W. SCHOENFELD1, J. MITTENDORF2, A. SCHMIDT2, U. GESCHKE2; |
1PLIVA d.d., Research and
Development, Zagreb, Croatia, 2Bayer AG, Pharma Research, Wuppertal, Germany. |
|
Wednesday, 8:30 a.m. - 10:00 a.m. |
221. Novel Antifungals and Antiparasitics |
2146. PLD-118: Tolerability, Safety and Pharmacokinetics Following Single
Oral Dose in Healthy Volunteers |
K. ORESKOVIC1, A. BISCHOFF2, A. SCHROEDTER2, J. KNOELLER2, H. PAVICIC-STEDUL, A. AVDAGIC, M. DUMIC, Z. KRALJ,W.
SCHOENFELD; |
1PLIVA d.d., Research and
Development, Zagreb, Croatia, 2FOCUS GmbH, Neuss, Germany. |
|
Wednesday, 8:30 a.m. - 10:00 a.m. |
221. Novel Antifungals and Antiparasitics |
2163. Safety and Clinical Pharmacokinetics of DB289, a New Orally
Bioavailable Dication |
P. YERAMIAN1, M. KRUSE2, A. KECSKES2, J. ALLEN1, L.
MCCHESNEY-HARRIS1, K. TRENDLER3, J. E. HALL4, R. TIDWELL4; |
1Immtech Intl., Inc., Vernon
Hills, IL, 2Parexel Inc., Berlin, Germany, 3Northwest Bioanalytical Inc., Salt Lake City, UT, 4Univ. of North
Carolina, Chapel Hill, NC. |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
225. Sepsis |
2216. The Protein Synthesis Inhibiting Clindamycin Improves Outcome in a
Mouse Model of Staphylococcus aureus Sepsis Compared to the Cell Wall Active
Ceftriaxone |
I. AZEH1, J. GERBER1, M. WELLHAUSEN1, H. EIFFERT2, R. NAU1; |
1Neurology, Univ. Hosp.,
Goettingen, Germany, 2Microbiol., Univ. Hosp., Goettingen |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
224. Antimicrobial Pharmacology |
2196. Determination of the Excitatory Potency of Faropenem in the CNS by
an In Vitro Model |
G. SCHMUCK, E. VON KEUTZ, A. DALHOFF; |
Bayer AG, Wuppertal, Germany. |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
224. Antimicrobial Pharmacology |
2207. Chondrotoxicity of Ofloxacin Compared with BMS 284,756 in Juvenile
Rats |
S. F. FASSHEBER1, E. M. KAPPEL2, K. RIECKE2, U. RAHM2, M. SHAKIBAEI3, R. STAHLMANN2; |
1Institute of Clinical
Pharmacology and Toxicology, Berlin, Germany, 2INSTITUTE of Clinical Pharmacology and Toxicology, Berlin,
Germany, 3Institute of Anatomy, Berlin, Germany. |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
225. Sepsis |
2216. The Protein Synthesis Inhibiting Clindamycin Improves Outcome in a
Mouse Model of Staphylococcus aureus Sepsis Compared to the Cell Wall Active
Ceftriaxone |
I. AZEH1, J. GERBER1, M. WELLHAUSEN1, H. EIFFERT2, R. NAU1; |
1Neurology, Univ. Hosp.,
Goettingen, Germany, 2Microbiol., Univ. Hosp., Goettingen |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
227. Miscellaneous Resistance |
2238. Occurrence of the Florfenicol Resistance Gene cfr in Staphylococci
of Human and Animal Origin |
S. SCHWARZ1, C. KEHRENBERG1, F.-J. SCHMITZ2; |
1Inst. Animal Sci. and Animal
Behaviour, Celle, Germany, 2Inst. Med. Microbiol. and Virol., Düsseldorf, Germany. |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
227. Miscellaneous Resistance |
2239. Chromosomal Location of Florfenicol Resistance Genes in Escherichia
coli |
B. DOUBLET1, S. SCHWARZ2, G. FRECH2, S. BAUCHERON1, J.-L. MARTEL3, E. CHASLUS-DANCLA1, A. CLOECKAERT1; |
1INRA, Nouzilly, France, 2Inst. Animal Sci.
and Animal Behaviour, Celle, Germany, 3AFSSA, Lyon, France. |
|
Wednesday, 10:00 a.m. - 11:30 a.m. |
230. In Vitro Susceptibility: Miscellaneous |
2264. Surveillance of Susceptibility Patterns in 1297 European and US
Anaerobic and Micro-Aerophilic Isolates to Amoxicillin/Clavulanic Acid (A/C)
and 5 Other Agents |
L. M. KOETH1, M. R. BISCOTTI1, P. C. APPELBAUM2, L. J. DUBREUIL3, E. J. C. GOLDSTEIN4, A. C. RODLOFF5; |
1Laboratory Specialists Inc,
Cleveland, OH, 2Hershey Medical Center, Hershey, PA, 3University of Lille,
Lille, France, 4RM Alden Research Foundation, Los Angeles, CA, 5University of
Leipzig, Leipzig, Germany. |
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